Ilya Strunilin

Program: Developmental Regenerative and Stem Cell Biology

Current advisor: Li Ding, PhD

Undergraduate university: Duke University, 2017

Enrollment year: 2017

Research summary
Molecular mechanism of Huntington’s Disease (HD) using patient-derived neurons as a model system

I study the molecular mechanism of Huntington’s Disease (HD) using patient-derived neurons as a model system. I am interested in why some HD patients have a much earlier onset of the disease relative to other patients with similar HD mutations. My hypothesis is that individual’s genetic makeup is affecting the age of onset of HD. Using patient-derived neurons I study the roles of candidate genes in the onset of HD and how turning off these genes can prevent the progression of HD.

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Graduate publications
Lee SW, Oh YM, Victor MB, Yang Y, Chen S, Strunilin I, Dahiya S, Dolle RE, Pak SC, Silverman GA, Perlmutter DH, Yoo AS. 2024 Longitudinal modeling of human neuronal aging reveals the contribution of the RCAN1-TFEB pathway to Huntington’s disease neurodegeneration. Nat Aging, 4(1):95-109. PMCID:

Wu Y, Terekhanova NV, Caravan W, Naser Al Deen N, Lal P, Chen S, Mo CK, Cao S, Li Y, Karpova A, Liu R, Zhao Y, Shinkle A, Strunilin I, Weimholt C, Sato K, Yao L, Serasanambati M, Yang X, Wyczalkowski M, Zhu H, Zhou DC, Jayasinghe RG, Mendez D, Wendl MC, Clark D, Newton C, Ruan Y, Reimers MA, Pachynski RK, Kinsinger C, Jewell S, Chan DW, Zhang H, Chaudhuri AA, Chheda MG, Humphreys BD, Mesri M, Rodriguez H, Hsieh JJ, Ding L, Chen F. 2023 Epigenetic and transcriptomic characterization reveals progression markers and essential pathways in clear cell renal cell carcinoma. Nat Commun, 14(1):1681. PMCID: PMC10042888