Kylie Schache

Program: Neurosciences

Current advisor: Celeste M. Karch, PhD

Undergraduate university: University of Michigan-Ann Arbor, 2022

Enrollment year: 2023

Research summary
My research is focused on defining the contribution of 4R tau-mediated impairment of the autophagy lysosome pathway in neurons and microglia to tauopathy pathophysiology and evaluating compounds which therapeutically target this pathway.

Graduate publications
Iyer AK, Vermunt L, Mirfakhar FS, Minaya M, Acquarone M, Koppisetti RK, Renganathan A, You SF, Danhash EP, Schache KJ, Verbeck A, Galasso G, Lee SM, Huang G, Miller KJ, Marsh J, Nana AL, Spina S, Seeley WW, Grinberg LT, Temple S, Teunissen CE, Sato C, Karch CM. 2025 Cell autonomous microglia defects in a stem cell model of frontotemporal dementia tau. Mol Psychiatry, 30(10):4776-91. PMCID: PMC12436154