Sofia Smith

Program: Molecular Genetics and Genomics

Current advisor: George P. Souroullas, PhD

Undergraduate university: University of Texas-Austin, 2020

Enrollment year: 2020

Research summary
My research aims to identify how gain-of-function events in EZH2, a histone methyltransferase, contribute to the development of mature B cell lymphoma.

Graduate publications
Zimmerman SM, Procasky SJ, Smith SR, Liu JY, Torrice C, Souroullas GP. 2025 Developmental stage and cellular context determine oncogenic and molecular outcomes of Ezh2 Y641F mutation in hematopoiesis. Blood Neoplasia, 2(3):100137. PMCID: PMC12356278

Zimmerman SM, Suh E, Smith SR, Souroullas GP. 2024 Stat3-mediated Atg7 expression regulates anti-tumor immunity in mouse melanoma. Cancer Immunol Immunother, 73(11):218. PMCID: 39235510

Zimmerman SM, Nixon SJ, Chen PY, Raj L, Smith SR, Paolini RL, Lin PN, Souroullas G. 2023 Ezh2Y641F mutations co-operate with Stat3 to regulate MHC class I antigen processing and alter the tumor immune response in melanoma. Oncogene, 41(46):4933-93. PMCID: PMC9669177