Yiyang Zhu

Program: Neurosciences

Current advisor: David M. Holtzman, MD

Undergraduate university: Grinnell College, 2020

Enrollment year: 2022

Research summary

Graduate publications
Cai Z, Wang S, Cao S, Chen Y, Penati S, Peng V, Yuede CM, Beatty WL, Lin K, Zhu Y, Zhou Y, Colonna M. 2025 Loss of ATG7 in microglia impairs UPR, triggers ferroptosis, and weakens amyloid pathology control. J Exp Med, 222(4):e20230173.. PMCID: PMC11823820

Zhu Y, Self WK, Holtzman DM. 2024 An emerging role for the gut microbiome in tauopathy. Neurotherapeutics, 21(6):e00423

Hou J, Chen Y, Cai Z, Heo GS, Yuede CM, Wang Z, Lin K, Saadi F, Trsan T, Nguyen AT, Constantopoulos E, Larsen RA, Zhu Y, Wagner ND, McLaughlin N, Kuang XC, Barrow AD, Li D, Zhou Y, Wang S, Gilfillan S, Gross ML, Brioschi S, Liu Y, Holtzman DM, Colonna M. 2024 Antibody-mediated targeting of human microglial leukocyte Ig-like receptor B4 attenuates amyloid pathology in a mouse model. Sci Transl Med, 16(741)::eadj9052. PMCID: PMC11977387

Chen Y, Song S, Parhizkar S, Lord J, Zhu Y, Strickland MR, Wang C, Park J, Tabor GT, Jiang H, Li K, Davis AA, Yuede CM, Colonna M, Ulrich JD, Holtzman DM. 2024 APOE3ch alters microglial response and suppresses Aβ-induced tau seeding and spread. Cell, 187(2):428-445.e20. PMCID: PMC10842861