Crystal Song

Program: Molecular Cell Biology

Current advisor: David M. Holtzman, MD

Undergraduate university: University of California-Los Angeles, 2020

Enrollment year: 2021

Research summary
Development of novel therapies for Alzheimer’s Disease

Graduate publications
Tabor GT, Litvinchuk A, Chen Y, Allison A, Sun EW, van Lengerich B, Davis SS, West E, Schlachetzki JCM, Zeng C, Hu H, Lin PB, Sharma P, Chen X, Parhizkar S, Song S, Bao X, Senthil L, Iyer AK, You SF, Serrano JR, Manis M, Franke E, Cashikar AG, Yuede CM, Suh JH, Karch CM, Folick A, Koliwad SK, Farese RV Jr, Walther T, Huang EJ, Artyomov M, Glass CK, Di Paolo G, Ulrich JD, Holtzman DM. 2026 Inducible deletion of DGAT1 and 2 from microglia exacerbates neurodegeneration and endolysosomal lipid accumulation in male PS19 mice. Cell Rep, 45(1):116841. PMCID:

Roberts KF, Landsness EC, Reese J, Elbert D, Strobel G, Wu E, Chen Y, Lai A, Abrams ZB, Zhu M, Melendez J, Koutarapu S, Song S, Chen Y, Lazar R, Barnaghi P, Crary JF, Sardi SP, Voss MD, Krishnan R, Schwartz JW, Mallon R, Jimenez-Maggiora GA, Wang C, Sandmann T, Bose N, Phatak M, Wittenberg G, Kevrekidis YG, Mitchell CS, Mitchener L, Raj T, Foschini L, Moore GJ, Bateman RJ. 2025 Towards an AI biomedical scientist: Accelerating discoveries in neurodegenerative disease. J Prev Alzheimers Dis, 13(1):00398. PMCID: PMC12811770

Parhizkar S, Bao X, Chen W, Rensing N, Chen Y, Kipnis M, Song S, Gent G, Tycksen E, Manis M, Lee C, Serrano JR, Bosch ME, Franke E, Yuede CM, Landsness EC, Wong M, Holtzman DM. 2025 Lemborexant ameliorates tau-mediated sleep loss and neurodegeneration in males in a mouse model of tauopathy. Nat Neurosci, 28(7):1460-72. PMCID: PMC12277058

Chen Y, Song S, Parhizkar S, Lord J, Zhu Y, Strickland MR, Wang C, Park J, Tabor GT, Jiang H, Li K, Davis AA, Yuede CM, Colonna M, Ulrich JD, Holtzman DM. 2024 APOE3ch alters microglial response and suppresses Aβ-induced tau seeding and spread. Cell, 187(2):428-445.e20. PMCID: PMC10842861