Kay Jayachandran

Program: Biomedical Informatics and Data Science

Current advisor: Jin Zhang, PhD, MPHS

Undergraduate university: University of Washington, 2018

Enrollment year: 2021

Research summary
Using NGS to understand the role of HPV in cervical cancer treatment and outcomes

Use various next generation sequencing techniques to understand the role of HPV in cervical cancer treatment and outcomes, including RNA sequencing, whole genome sequencing, and single cell RNA sequencing.

Graduate publications
Sandoval TA, Li Y, Muhammad N, Desai T, Jayasinghe RG, Zeeshan S, Jayachandran K, Inkman MJ, Waters MR, Msengi ENS, McKinnish TR, Hatipoglu I, Paschoalini Mafra AC, Anwar M, Hu D, Bhatt DP, Lander VE, Mashl RJ, Houston A, Chen L, Contreras J, Robinson CG, Davies SR, Belmar J, Li S, Major MB, DeNardo DG, Markovina S, Edelson BT, Zhang J, Ding L, Schwarz JK. 2026 Chemoradiation Reprograms Tumor Cells and the Immune Microenvironment in Cervical Cancer. Cancer Res, 86(7):1639-56. PMCID: PMC13007708

Fowle-Grider R, Rowles JL 3rd, Shen I, Wang Y, Schwaiger-Haber M, Dunham AJ, Jayachandran K, Inkman M, Zahner M, Naser FJ, Jackstadt MM, Spalding JL, Chiang S, McCommis KS, Dolle RE, Kramer ET, Zimmerman SM, Souroullas GP, Finck BN, Shriver LP, Kaufman CK, Schwarz JK, Zhang J, Patti GJ. 2024 Dietary fructose enhances tumour growth indirectly via interorgan lipid transfer. Nature, 636(8043):737-44. PMCID: PMC12276860

Chen L, Shi V, Wang S, Sun L, Freeman R, Yang J, Inkman MJ, Ghosh S, Ruiz F, Jayachandran K, Huang Y, Luo J, Zhang J, Cosper P, Luke CJ, Spina CS, Grigsby PW, Schwarz JK, Markovina S. 2023 SCCA1/SERPINB3 suppresses antitumor immunity and blunts therapy-induced T cell responses via STAT-dependent chemokine production. J Clin Invest, 133(15)::e163841. PMCID: PMC10378164

Muhammad N, Ruiz F, Stanley J, Rashmi R, Cho K, Jayachandran K, Zahner MC, Huang Y, Zhang J, Markovina S, Patti GJ, Schwarz JK. 2022 Monounsaturated and Diunsaturated Fatty Acids Sensitize Cervical Cancer to Radiation Therapy. Cancer Res, 82(24)::4515-27. PMCID: PMC9772149