Biochemistry, Biophysics & Structural Biology Faculty

   
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  • Nada A. Abumrad, PhD - Fatty acids regulate energy balance and tissue renewal. Dysfunction of this regulation causes disease
  • Jennifer Alexander-Brett, MD, PhD - Respiratory immunobiology, with particular interest in cytokine pathways associated with lung epithelial progenitors
  • Ream Al-Hasani, PhD - Understanding the endogenous opioid systems to defeat addiction, ameliorate affective disorders, and relieve chronic pain.
  • Gaya K. Amarasinghe, PhD - Molecular mechanisms at the host-pathogen interface
  • Maxim Artyomov, PhD - Systems immunology using high-throughput next-generation sequencing in conjunction with mathematical and statistical modeling approaches rooted in statistical physics
  • Monika Bambouskova, PhD - Immunometabolism - metabolic regulation of immune cell activation
  • Thomas J. Baranski, MD, PhD - Signal transduction by G proteins and pathogenesis of diabetes
  • David L. Bark, PhD - Applying biomechanics and mechanobiology (the interaction and response of cells and tissue to mechanical forces) to diagnose, study, and treat various forms of cardiovascular disease.
  • Wayne M. Barnes, PhD - Possible cure for MS: intravenous access by myelin-binding aptamer; PCR at one temp; RT-enabled Taq pol.
  • Philip V. Bayly, PhD - The application of nonlinear dynamics and vibrations to mechanical and biomedical systems
  • Mikhail Berezin, PhD - Investigation the mechanism of peripheral neuropathies
  • Matthew R. Bersi, PhD - Our research is focused on soft tissue biomechanics and mechanobiology
  • Joshua Blodgett, PhD - Interdisciplinary questions surrounding bacterial small molecule production
  • Kendall J. Blumer, PhD - Tumor cell biology, signal transduction, and drug development
  • Irving Boime, PhD - Placental and pituitary hormone genes
  • Ron Bose, MD, PhD - Genomics and Cell Signaling in Breast Cancer
  • Thomas J. Brett, PhD - The molecular basis of lung diseases and drug development using structural biology tools
  • Peter M.J. Burgers, PhD - Molecular Biology of DNA replication and damage response in yeast and human
  • Michael G. Caparon, Jr, PhD - Genetics and virulence of the pathogenetic streptococci
  • Anders E. Carlsson, PhD - Simulation and theory of force generation by actin polymerization
  • Valeria Cavalli, PhD - Cellular, Molecular and Epigenetic control of axon regeneration
  • Baron Chanda, PhD - Mechanisms and Design Principles of Ion Channel Function and Gating
  • Tao Che, PhD - Characterizing and dissecting the molecular mechanisms of opioid receptor signaling
  • Yao Chen, PhD - Understanding the function of neuromodulators and sleep through the spatiotemporal dynamics of molecular signals
  • Ying Maggie Chen, MD, PhD - Understanding the molecular mechanisms of primary nephrotic syndrome (NS)
  • Zhou-Feng Chen, PhD - affective touch, itch, pain, GPCR and prosocial behavior
  • Wayland W. L. Cheng, MD, PhD - I am interested in the structure and function of neuronal ligand-gated ion channels, and the mechanism of channel modulation by endogenous lipids or exogenous drugs such as general anesthetics.
  • ShiNung Ching, PhD - The interface between systems and control engineering, neuroscience and neural medicine
  • Jaehyung (Gus) Cho, PhD - Understanding the mechanism mediating intravascular cell-cell interactions and vascular occlusion under thromboinflammatory conditions, including thrombosis, ischemia/reperfusion injury, and sickle cell disease
  • Bryan Copits, PhD - We study how different types of neurons encoding somatosensory modalities are assembled into functional circuits in both humans and model organisms.
  • Clair Crewe, PhD - Understanding extracellular vesicle (EV)-mediated signaling during homeostatic and pathologic metabolic regulation
  • Erika C. Crouch, PhD, MD - Structure and function of surfactant protein D (SP-D)
  • Jianmin Cui, PhD - Molecular basis of bioelectricity and related diseases in nervous and cardiovascular systems; ion channel function and modulation; discovery of drugs that target ion channels
  • Nicholas O. Davidson, MD - Mammalian gene expression: Regulation through mRNA editing and RNA stabilization
  • Gus Davis, MD, PhD - Understanding the molecular and cellular mechanisms of protein aggregation and neurodegeneration in Parkinson disease and dementia with Lewy bodies
  • Ram Dixit, PhD - Molecular mechanisms of cytoskeleton organization and function
  • Sergej Djuranovic, PhD - Molecular mechanisms of translational control
  • Tamara L. Doering, MD, PhD - Biology and pathogenesis of the pathogenic fungus Cryptococcus neoformans
  • Gabor Egervari, PhD - We aim to understand how metabolism influences epigenetics, gene expression and behavior, particularly in the context of substance use disorders and neurodegeneration
  • Adam T. Eggebrecht, PhD - Developing novel tools that extend mapping of brain function beyond current limitations
  • Bahaa E. Elgendy, PhD - Medicinal chemistry with a broad goal of drug design and organic synthesis
  • Elliot L. Elson, PhD - Mechanical properties of reconstituted tissues; fluctuation spectroscopy of protein interactions
  • Alex S. Evers, MD - Molecular mechanisms of anesthetic action - Proteomics of GABAA receptors
  • Daved H. Fremont, PhD - Mechanisms of host immunity and viral evasion
  • Eric A. Galburt, PhD - Biophysical studies of transcription initiation in Eukaryotes and Mycobacterial tuberculosis
  • Roberto Galletto, PhD - Mechanistic studies of DNA motor proteins; single Molecule Biochemistry
  • Guy M. Genin, PhD - Interfaces and adhesions in physiology and nature
  • Daniel E. Goldberg, MD, PhD - Biochemistry of malaria
  • Dennis Goldfarb, PhD - Computational mass spectrometry and proteomics
  • Gregory A. Grant, PhD - Relationship of structure to function in allosteric control mechanisms
  • Michael J. Greenberg, PhD - The Greenberg lab seeks to understand the molecular and cellular biophysics of heart disease, with the goal of engineering disease models and precision therapeutics
  • Michael L. Gross, PhD - Development and application of mass spectrometry in biophysics, biochemistry, and medicine
  • Richard W. Gross, MD, PhD - The molecular mechanisms through which biologic membranes participate in cellular activation processes
  • Kathleen B. Hall, PhD - We study RNA folding and RNA binding to proteins
  • Jeffrey Haspel, MD, PhD - Understand the impact of time as a biological variable in the development of critical illness such as sepsis, respiratory failure and chronic inflammatory lung disease
  • Jen M. Heemstra, PhD - Utilization of nucleic acid molecular recognition and self-assembly to generate functional architectures for biosensing and bioimaging
  • Jason M. Held, PhD - Redox biochemistry in cell signaling and disease, Proteomics
  • Jeffrey P. Henderson, MD, PhD - Biochemical interactions between humans and bacteria in health and disease
  • Alex Holehouse, PhD - Understand how function is encoded into disordered sequences using a combination of computational and experimental approaches
  • James E. Huettner, PhD - Glutamate receptors, synaptic transmission and stem cell differentiation
  • Scott J. Hultgren, PhD - Interdisciplinary approach combining genetics, genomics, biochemistry, structural biology, high-resolution imaging, animal models, clinical studies and combinatorial chemistry to determine key aspects of bacterial pathogenesis and apply our knowledge to development of new therapeutics.
  • Joseph Ippolito, MD, PhD - Precision medicine through metabolism-based imaging and therapy: from laboratory to clinical translation
  • Meredith E. Jackrel, PhD - Protein folding and misfolding, and the engineering and application of protein disaggregases to reverse misfolding
  • James W. Janetka, PhD - The rational structure-based drug design and synthesis for cancer and infectious disease
  • Silvia Jansen, PhD - we study the molecular mechanisms that regulate the architecture, dimensions and dynamics of actin filament networks, and tune them to support essential cellular functions including cell migration, intracellular trafficking and cytokinesis.
  • Joseph Jez, PhD - Exploring regulatory networks in metabolism - structural biology and biochemistry of plants and microbes
  • Tao Ju, PhD - Developing geometric algorithms for interpreting protein structures from low-resolution density maps produced by cryo-electron microscopy and X-ray crystallography
  • David Kast, PhD - Understand fundamental cellular and molecular mechanisms that drive the biogenesis and dynamics of intracellular membrane compartments
  • Dineo Khabele, MD - clinical and translational research in gynecologic oncology, with a focus on ovarian cancer
  • S. Kerry Kornfeld, MD, PhD - organismal aging; zinc homeostasis and roles of zinc during cell differentiation.
  • Sándor J. Kovács, PhD, MD - Quantitative cardiovascular physiology, mathematical modeling of systems physiology, imaging
  • Albert M. Lai, PhD - My research is in clinical research informatics, but I also have strong interest in other areas of clinical informatics, including usability of clinical and consumer-facing systems and mobile health
  • Gregory M. Lanza, MD, PhD - Noninvasive molecular imaging and drug delivery research
  • Daisy W. Leung, PhD - Defining molecular mechanisms at the host-pathogen interface
  • Petra Anne Levin, PhD - Bacterial growth and antibiotic susceptibility
  • Matthew D. Lew, PhD - Developing novel optical imaging technologies for studying biomolecular activities at the nanoscale
  • Jr-Shin Li, PhD - Control and optimization of large-scale complex systems with applications ranging from quantum mechanics and neuroscience to bioinformatics
  • Weikai Li , PhD - Membrane protein structure and function
  • Christopher J. Lingle, PhD - Structure-function studies of Slo family K+ channels
  • Timothy M. Lohman, PhD - Mechanisms of DNA helicases/translocases and SSB proteins
  • Nupam P. Mahajan, PhD - How tyrosine phosphorylation regulates epigenetic processes that affect cellular homeostasis and cancer cell survival
  • Moe Mahjoub, PhD - The microtubule cytoskeleton in health and disease
  • Ben Major, PhD - Studying how perturbation of specific signal transduction pathways contributes to the initiation, progression and dissemination of cancer
  • Susruta Majumdar, PhD - Research in the laboratory is aimed at attaining functional selectivity of opioid agonist action from its own target adverse effects while integrating chemical synthesis with biochemical, genetic and pharmacological approaches.
  • Jordan G. McCall, PhD - Understanding the neural mechanisms underlying emotional dysregulation in the contexts of stress, chronic pain, and addiction
  • William H. McCoy, MD, PhD - We investigate how host-microbe interactions at epithelial barrier sites impact skin diseases.
  • Mark Meacham, PhD - Studies microfluidics, micro-electromechanical systems and associated transport phenomena
  • Robert W. Mercer, PhD - Molecular and cell biology of ion pumps and transporters in plasma membrane; cell polarity
  • Timothy M. Miller, MD, PhD - Mechanisms of neurodegeneration and targeted therapies for neurodegenerative diseases
  • Liviu M. Mirica, PhD - Development of specific inhibitors of histone demethylases; design of therapeutic and imaging chemical agents for Alzheimer's disease
  • Makedonka Mitreva, PhD - Next-generation experimental, multi-omic and computational approaches to empower the study of infectious diseases and the human microbiome
  • Kevin D. Moeller, PhD - Developing new methods for peptide mimetic, natural product synthesis, and the construction of addressable molecular arrays
  • Tae Seok Moon, PhD - Building the Future with Synthetic Biology
  • Jose A. Moron-Concepcion, PhD - Elucidating the molecular mechanisms underlying opiate dependence
  • Nima Mosammaparast, MD, PhD - Understanding how RNA modifications influence transcription, signaling, and genomic integrity
  • Colin G. Nichols, PhD - Ion channel biology in health and disease
  • Natalie M. Niemi, PhD - Understanding how mitochondria are built, regulated, and maintained
  • Dmitri A. Nusinow, PhD - Circadian clock regulation of physiology and development in plants.
  • Dave Pagliarini, PhD - We seek to understand the cellular and biochemical underpinnings of mitochondrial dysfunction in human diseases. Our work integrates large-scale methodologies with traditional biochemistry and cell biology to investigate the modulation, adaptation, and basic metabolic function of mitochondria.
  • Himadri B. Pakrasi, PhD - Systems and Synthetic Biology of photosynthetic organisms
   
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