Aishwarya Krishnan

Program: Cancer Biology

Current advisor: Grant Challen, PhD

Undergraduate university: MS Ramaiah Institute of Technology, 2015

Enrollment year: 2021

Research summary
Investigating the mechanistic role of IFNg in the clonal expansion of Dnmt3a-mutant hematopoietic stem cells (HSCs)

Graduate publications
Xavier Raj I, Kyun Koh W, Harrison J, Zhang CR, Soares B, Amato R, Krishnan A, O’Leary DR, Bjeije H, Parsons TM, Han W, Young AL, Wang T, Batista LFZ, Challen GA. 2025 Non-canonical functions of DNMT3A in hematopoietic stem cells regulate telomerase activity and genome integrity. Cell Stem Cell, 32(8):1251-1266.e8. PMCID: PMC12313198

Krishnan A, Miles LA, Challen GA. 2025 Cell-extrinsic factors contribute toward myeloid-biased expansion in Tet2-mutant clonal hematopoiesis. Exp Hematol, 148():104816

Dunuwille W, Wilson WC, Bjeije H, IssaN, Han W, Parsons TM, Young AL, Raj IX, Krsihnan A, Gaur T, Wang ES, Weng AP, Stubbs MC, Celik H, Cashen AF, Edwards JR, Challen GA. 2024 BIRC5 upregulation enhances DNMT3A-mutant T-ALL cell survival and pathogenesis. Blood Neoplasia, 1(4):100040. PMCID: PMC12182843

Parsons TM, Krishnan A, Dunuwille WMB, Young AL, Arand J, Han W, Challen GA. 2024 Engineering a humanized animal model of polycythemia vera with minimal JAK2 V617F mutant allelic burden. Haematologica, 109(3):968-73. PMCID: PMC10905086

Issa N, Bjeije H, Wilson ER, Krishnan A, Dunuwille WMB, Parsons TM, Zhang CR, Han W, Young AL, Ren Z, Ge K, Wang ES, Weng AP, Cashen A, Spencer DH, Challen GA. 2023 KDM6B protects T-ALL cells from NOTCH1-induced oncogenic stress. Leukemia, 37(4):728-40. PMCID: PMC10081958