Alexander Liu

Program: Immunology

Current advisor: Marco Colonna, MD

Undergraduate university: Case Western Reserve University, 2021

Enrollment year: 2022

Research summary
Developing Novel Chimeric Antigen Receptor Astrocyte (CAR-A) Therapy for Alzheimer’s Disease

My research focuses on developing novel cellular-based Chimeric Antigen Receptor Astrocyte (CAR-A) therapy to target amyloid pathology for Alzheimer’s Disease.

Graduate publications
Rodrigues PF, Wu S, Trsan T, Panda SK, Fachi JL, Liu Y, Du S, de Oliveira S, Antonova AU, Khantakova D, Sudan R, Desai P, Diamond MS, Gilfillan S, Anderson SK, Cella M, Colonna M. 2025 Rorγt-positive dendritic cells are required for the induction of peripheral regulatory T cells in response to oral antigens. Cell, 188(10):2720-2737.e22. PMCID: PMC12085292

Molgora M, Liu YA, Colonna M, Cella M. 2023 TREM2: A new player in the tumor microenvironment. Semin Immunol, 67():101739

Pfeifer CW, Walsh JT, Santeford A, Lin JB, Beatty WL, Terao R, Liu YA, Hase K, Ruzycki PA, Apte RS. 2023 Dysregulated CD200-CD200R signaling in early diabetes modulates microglia-mediated retinopathy. Proc Natl Acad Sci USA, 120(45):e2308214120. PMCID: PMC10636339