Anthony Wang

Program: Immunology

Current advisor: Gavin P. Dunn, MD, PhD

Undergraduate university: Rice University, 2018

Enrollment year: 2019

Research summary
Investigating GZMK+ T cells as a major subset of glioblastoma-infiltrating CD8 T cells

This year I have been working in the lab of Dr. Gavin Dunn in the Department of Neurosurgery at MGH. The Dunn lab studies glioblastoma multiforme (GBM) which is the most aggressive glioma and is generally associated with poor prognosis. My main project involves investigating the role of GZMK+ T cells in the tumor microenvironment.

Graduate publications
Wang AZ, Mashimo BL, Schaettler MO, Sherpa ND, Leavitt LA, Livingstone AJ, Khan SM, Li M, Anzaldua-Campos MI, Bradley JD, Leuthardt EC, Kim AH, Dowling JL, Chicoine MR, Jones PS, Choi BD, Cahill DP, Carter BS, Petti AA, Johanns TM, Dunn GP. 2024 Glioblastoma-Infiltrating CD8+ T Cells Are Predominantly a Clonally Expanded GZMK+ Effector Population. Cancer Discov, 14(6):1106-31. PMCID:

Kong T, Laranjeira ABA, Yang K, Fisher DAC, Yu L, Poittevin De La Frégonnière L, Wang AZ, Ruzinova MB, Fowles JS, Fulbright MC, Cox MJ, Celik H, Challen GA, Huang S, Oh ST. 2023 DUSP6 mediates resistance to JAK2 inhibition and drives leukemic progression. Nat Cancer, 4(1):108-127. PMCID:

Bowman-Kirigin JA, Desai R, Saunders BT, Wang AZ, Schaettler MO, Liu CJ, Livingstone AJ, Kobayashi DK, Durai V, Kretzer NM, Zipfel GJ, Leuthardt EC, Osbun JW, Chicoine MR, Kim AH, Murphy KM, Johanns TM, Zinselmeyer BH, Dunn GP. 2023 The Conventional Dendritic Cell 1 Subset Primes CD8+ T Cells and Traffics Tumor Antigen to Drive Antitumor Immunity in the Brain. Cancer Immunol Res, 11(1):20-37. PMCID: PMC10725570

Schaettler MO, Desai R, Wang AZ, Livingstone AJ, Kobayashi DK, Coxon AT, Bowman-Kirigin JA, Liu CJ, Li M, Bender DE, White MJ, Kranz DM, Johanns TM, Dunn GP. 2023 TCR-engineered adoptive cell therapy effectively treats intracranial murine glioblastoma. J Immunother Cancer, 11(2):e006121. PMCID: PMC9944319

Schaettler MO, Richters MM, Wang AZ, Skidmore ZL, Fisk B, Miller KE, Vickery TL, Kim AH, Chicoine MR, Osbun JW, Leuthardt EC, Dowling JL, Zipfel GJ, Dacey RG, Lu HC, Johanns TM, Griffith OL, Mardis ER, Griffith M, Dunn G. 2022 Characterization of the Genomic and Immunologic Diversity of Malignant Brain Tumors through Multisector Analysis. Cancer Discov, 12(1):154-71. PMCID: PMC9296070

Wang AZ, Bowman-Kirigin JA, Desai R, Kang LI, Patel PR, Patel B, Khan SM, Bender D, Marlin MC, Liu J, Osbun JW, Leuthardt EC, Chicoine MR, Dacey RG Jr, Zipfel GJ, Kim AH, DeNardo DG, Petti AA, Dunn GP. 2022 Single-cell profiling of human dura and meningioma reveals cellular meningeal landscape and insights into meningioma immune response. Genome Med, 14(1):49. PMCID: PMC9088131