Bishan Bhattarai

Program: Molecular Microbiology and Microbial Pathogenesis

Current advisor: Marco Colonna, MD

Undergraduate university: University of Richmond, 2016

Enrollment year: 2019

Research summary

Graduate publications
Fachi JL, de Oliveira S, Trsan T, Penati S, Gilfillan S, Cao S, Ribeiro Castro P, Fernandes MF, Hyrc KL, Liu X, Rodrigues PF, Bhattarai B, Layden BT, Vinolo MAR, Colonna M. 2025 Fiber- and acetate-mediated modulation of MHC-II expression on intestinal epithelium protects from Clostridioides difficile infection. Cell Host Microbe, 33(2):235-251.e7. PMCID:

Rea A, Santana-Hernández S, Villanueva J, Sanvicente-García M, Cabo M, Suarez-Olmos J, Quimis F, Qin M, Llorens E, Blasco-Benito S, Torralba-Raga L, Perez L, Bhattarai B, Alari-Pahissa E, Georgoudaki AM, Balaguer F, Juan M, Pardo J, Celià-Terrassa T, Rovira A, Möker N, Zhang C, Colonna M, Spanholtz J, Malmberg KJ, Montagut C, Albanell J, Güell M, López-Botet M, Muntasell. 2025 Enhancing human NK cell antitumor function by knocking out SMAD4 to counteract TGFβ and activin A suppression. Nat Immunol, 26(4):582-94. PMCID: PMC11957989

Peng V, Trsan T, Sudan R, Bhattarai B, Cortez VS, Molgora M, Vacher J, Colonna M. 2024 Inositol phosphatase INPP4B sustains ILC1s and intratumoral NK cells through an AKT-driven pathway. J Exp Med, 221(3):e20230124. PMCID: PMC10783437

Di Luccia B, Molgora M, Khantakova D, Jaeger N, Chang HW, Czepielewski RS, Helmink BA, Onufer EJ, Fachi JL, Bhattarai B, Trsan T, Rodrigues PF, Hou J, Bando JK, da Silva CS, Cella M, Gilfillan S, Schreiber RD, Gordon JI, Colonna M.. 2024 TREM2 deficiency reprograms intestinal macrophages and microbiota to enhance anti-PD-1 tumor immunotherapy. Sci Immunol, 9(95):eadi5374. PMCID: