Brian Egan

Program: Molecular Cell Biology

Current advisor: S. Kerry Kornfeld, MD, PhD

Undergraduate university: Boston College, 2014

Enrollment year: 2016

Research summary
Understanding the mechanisms by which genetic and pharmacological interventions affect aging and longevity in the nematode Caenorhabditis elegans

Graduate publications
Egan BM, Scharf A, Pohl F, Kornfeld K. 2022 Control of aging by the renin-angiotensin system: a review of C. elegans, Drosophila, and mammals. Front Pharmacol, 13():938650

Scharf A, Pohl F, Egan BM, Kocsisova Z, Kornfeld K. 2021 Reproductive Aging in Caenorhabditis elegans: From Molecules to Ecology. Front Cell Dev Biol, 9():718522

Kumar S, Egan BM, Kocsisova Z, Schneider DL, Murphy JT, Diwan A, Kornfeld K. 2019 Lifespan Extension in C. elegans Caused by Bacterial Colonization of the Intestine and Subsequent Activation of an Innate Immune Response. Dev Cell, 49(1):100-17. PMCID:

Murphy JT, Liu H, Ma X, Shaver A, Egan BM, Oh C, Boyko A, Mazer T, Ang S, Khopkar R, Javaheri A, Kumar S, Jiang X, Ory D, Mani K, Matkovich SJ, Kornfeld K, Diwan A. Simple nutrients bypass the requirement for HLH-30 in coupling lysosomal nutrient sensing to survival.. PLoS Biol, 17(5):e300024. PMCID: