Caleb Lines

Program: Cancer Biology

Current advisor: Jason D. Weber, PhD

Undergraduate university: Wartburg College, 2022

Enrollment year: 2023

Research summary
Selective translation in endometrial cancer when altering select interferon stimulated genes

I study mechanisms of selective translation that occurs in endometerial cancer due to activation or loss of interferon stimulated gene activity. I employ techniques such as cell culture, qPCR, western blotting, polysome profiling, and flow cytometry among others to elucidate the translational changes that might be occuring to make endometrial cancer cell lines more or less resistant to alterations in interferon stimulated genes.

Graduate publications
Welp AM, Lines CL, Bahnks BA, Mutch DG, Mullen MM, Weber JD. 2026 Evaluating the relationship and therapeutic-targeting potential of STING, ADAR1, and DHX9 in p53-mutated endometrial cancer lines. , ():

Lines CL. 2026 ADAR1 and DHX9 support p53abn Uterine Corpus Endometrial Cancer (UCEC Survival and Proliferation. , ():

Lines CL, Bahnks BA, Mabry A, Bancks M, Welp AM, Maggi Jr LB, Weber JD. 2025 ADAR1 and DHX9 represent a therapeutic opportunity in p53-mutated endometrial cancer. , ():