Colin McCornack

Program: Computational and Systems Biology

Current advisor: Ting Wang, PhD

Undergraduate university: Michigan State University, 2018

Enrollment year: 2019

Research summary
Impact of epigenetic therapy on transposable elements

Broadly, the focus of my research in the Wang lab involves investigating a) the regulation of transposable element expression/exaptation in the context of epigenetic therapy (such as DNA methyltransferase inhibition and histone posttranslational modifying enzyme inhibition), b) changes to transcription factor recruitment and regulation in the context of epigenetic therapy, with a specific focus on p53-driven transcriptional activation and repression, and c) how expression TE-membrane protein chimeras changes in the context of epigenetic therapy.

Graduate publications
Sun R, Han R, McCornack C, Khan S, Tabor GT, Chen Y, Hou J, Jiang H, Schoch KM, Mao DD, Cleary R, Yang A, Liu Q, Luo J, Petti A, Miller TM, Ulrich JD, Holtzman DM, Kim AH. 2023 TREM2 inhibition triggers antitumor cell activity of myeloid cells in glioblastoma. Sci Adv, 9(19):eade3559. PMCID: PMC10181199