Daniel Griffith

Program: Computational and Systems Biology

Current advisor: Alex Holehouse, PhD

Undergraduate university: University of Wisconsin-Madison, 2019

Enrollment year: 2019

Research summary
Understanding the relationship between intrinsically disordered protein sequence and function.

Graduate publications
Boeynaems S, Dorone Y, Zhuang Y, Shabardina V, Huang G, Marian A, Kim G, Sanyal A, Sen NE, Griffith D, Docampo R, Lasker K, Ruiz-Trillo I, Auburger G, Holehouse AS, Kabashi E, Lin Y, Gitler AD. 2023 Poly(A)-binding protein is an ataxin-2 chaperone that regulates biomolecular condensates. Mol Cell, 83(12):2020-2034.e6. PMCID:

Griffith D, Holehouse AS. 2021 PARROT is a flexible recurrent neural network framework for analysis of large protein datasets. Elife, ():e70576. PMCID: PMC8448528

Holehouse AS, Ginell GM, Griffith D, Böke E. 2021 Clustering of Aromatic Residues in Prion-like Domains Can Tune the Formation, State, and Organization of Biomolecular Condensates. Biochemistry, 60(47):3566-81. PMCID: PMC8638251

Emenecker RJ, Griffith D, Holehouse AS. 2021 Metapredict: a fast, accurate, and easy-to-use predictor of consensus disorder and structure. Biophys J, 120(20):4312-19. PMCID: PMC8553642

Cubuk J, Alston JJ, Incicco JJ, Singh S, Stuchell-Brereton MD, Ward MD, Zimmerman MI, Vithani N, Griffith D, Wagoner JA, Bowman GR, Hall KB, Soranno A, Holehouse AS. 2021 The SARS-CoV-2 nucleocapsid protein is dynamic, disordered, and phase separates with RNA. Nat Commun, 12(1):1936. PMCID: PMC8007728