Darya Khantakova

Program: Cancer Biology

Current advisor: Marco Colonna, MD

Undergraduate university: Novosibirsk State University, 2019

Enrollment year: 2020

Research summary
Innate immune cells in the tumor microenvironment

Graduate publications
Rodrigues PF, Wu S, Trsan T, Panda SK, Fachi JL, Liu Y, Du S, de Oliveira S, Antonova AU, Khantakova D, Sudan R, Desai P, Diamond MS, Gilfillan S, Anderson SK, Cella M, Colonna M. 2025 Rorγt-positive dendritic cells are required for the induction of peripheral regulatory T cells in response to oral antigens. Cell, 188(10):2720-2737.e22. PMCID: PMC12085292

Di Luccia B, Molgora M, Khantakova D, Jaeger N, Chang HW, Czepielewski RS, Helmink BA, Onufer EJ, Fachi JL, Bhattarai B, Trsan T, Rodrigues PF, Hou J, Bando JK, da Silva CS, Cella M, Gilfillan S, Schreiber RD, Gordon JI, Colonna M.. 2024 TREM2 deficiency reprograms intestinal macrophages and microbiota to enhance anti-PD-1 tumor immunotherapy. Sci Immunol, 9(95):eadi5374. PMCID:

Rodrigues PF, Trsan T, Cvijetic G, Khantakova D, Panda SK, Liu Z, Ginhoux F, Cella M, Colonna M. 2024 Progenitors of distinct lineages shape the diversity of mature type 2 conventional dendritic cells. Immunity, 57(7):1567-1585.e5. PMCID:

Sultan H, Takeuchi Y, Ward JP, Sharma N, Liu TT, Sukhov V, Firulyova M, Song Y, Ameh S, Brioschi S, Khantakova D, Arthur CD, White JM, Kohlmiller H, Salazar AM, Burns R, Costa HA, Moynihan KD, Yeung YA, Djuretic I, Schumacher TN, Sheehan KCF, Colonna M, Allison JP, Murphy KM, Artyomov MN, Schreiber RD. 2024 Neoantigen-specific cytotoxic Tr1 CD4 T cells suppress cancer immunotherapy. Nature, 632(8023):182-91. PMCID: PMC11291290

Timperi E, Croizer H, Khantakova D, Rana M, Molgora M, Guerriero JL, Mechta-Grigoriou F, Romano E. 2024 At the Interface of Tumor-Associated Macrophages and Fibroblasts: Immune-Suppressive Networks and Emerging Exploitable Targets. Clin Cancer Res, 30(23):5242-51

Khantakova D, Brioschi S, Molgora M. 2022 Exploring the Impact of TREM2 in Tumor-Associated Macrophages. Vaccines (Basel), 10(6):943