David O'leary

Program: Cancer Biology

Current advisor: Grant Challen, PhD

Undergraduate university: Truman State University, 2020

Enrollment year: 2023

Research summary
Investigating the functional effects of DNMT3A mutations in hematopoietic stem cells on immune cell development and activity in the context of clonal hematopoiesis.

Graduate publications
Xavier Raj I, Kyun Koh W, Harrison J, Zhang CR, Soares B, Amato R, Krishnan A, O’Leary DR, Bjeije H, Parsons TM, Han W, Young AL, Wang T, Batista LFZ, Challen GA. 2025 Non-canonical functions of DNMT3A in hematopoietic stem cells regulate telomerase activity and genome integrity. Cell Stem Cell, 32(8):1251-1266.e8. PMCID: PMC12313198