Irenaeus Chi-Chung Chan

Program: Cancer Biology

Current advisor: Kelly L. Bolton, MD, PhD

Undergraduate university: University of Guelph, 2016

Enrollment year: 2024

Research summary
Understanding how cell-extrinsic determinants of clonal hematopoiesis (CH) – specifically, modifiable lifestyle and psychosocial risk factors which constitutes an unhealthy lifestyle shapes clonal dynamics and evolution; to reduce CH-related disease risk.

Graduate publications
Chan ICC, Zhang P, Pan X, Castro C, Fox N, Lewis AM, Weis K, Cuibus A, Tittley S, Petrone G, Beeler JS, Tran D, Mustion G, Fronick C, Stopsack KH, Cruchaga C, Abdel-Wahab O, Bolton KL. 2026 CDK4/6 inhibition mitigates chemotherapy-induced expansion of TP53-mutant clonal hematopoiesis. Nat Genet, 58(3):582-92. PMCID: PMC12987733

Hubbard AK, Brown DW, Liu J, Chan IC, Zhou W, Genovese G, DePaulis A, Srinivasan S, Lin SH, Blechter B, Buller ID, Zeng Q, Cao Y, Huang WY, Freedman ND, Zhang H, Dutta D, Chanock SJ, Bolton KL, Machiela MJ.. 2025 Integration of Germline and Somatic Variation Improves Chronic Lymphocytic Leukemia Risk Stratification. Cancer Res, 85(14):2743-52. PMCID: PMC12263322

Liu J, Tran D, Xue L, Wiley BJ, Vlasschaert C, Watson CJ, MacGregor HAJ, Zong X, Chan ICC, Das I, Uddin MM, Niroula A, Griffin G, Ebert BL, Mack T, Pershad Y, Sharber B, Berger M, Zehir A, Ptashkin R, Levine RL, Papaemmanuil E, Joseph V, Gao T, Kemel Y, Mandelker D, Stopsack KH, Pharoah PDP, Mukherjee S, Ding L, Cao Y, Walter MJ, Blundell JR, Chatterjee N, Offit K, Godley LA, Link DC, Stadler ZK, Bick AG, Natarajan P, Bolton KL. 2025 Germline genetic variation impacts clonal hematopoiesis landscape and progression to malignancy. Nat Genet, 57(8):1872-80. PMCID: PMC12339400

Machiela MJ, Wong WSW, Mai JZ, Karyadi DM, Drozdovitch V, Chan I, Vij V, Zhou W, Luo W, Wu D, Hutchinson A, Jones K, Hicks B, Bakhanova E, Chumak V, Gudzenko N, Kryuchkov V, Golovanov I, Bolton K, Cahoon EK, Morton LM, Bazyka D, Chanock SJ. 2025 Risk of clonal hematopoiesis in families exposed to radiation following the Chornobyl accident. Carcinogenesis, 63(3):bgaf056. PMCID: PMC12558148