Jason Colasanti

Program: Molecular Cell Biology

Current advisor: Rajendra S. Apte, MD, PhD

Undergraduate university: University of Maryland-College Park, 2017

Enrollment year: 2018

Research summary
Investigating the molecular mechanisms of aging, longevity, and cellular senescence. Leading a number of projects involving age-related ocular diseases, variability in gene-expression with age, and the impacts of circadian rhythm alterations on lifespan.

Graduate publications
Terao R, Sohn BS, Yamamoto T, Lee TJ, Colasanti J, Pfeifer CW, Lin JB, Santeford A, Yamaguchi S, Yoshida M, Apte RS. 2024 Cholesterol Accumulation Promotes Photoreceptor Senescence and Retinal Degeneration. Invest Ophthalmol Vis Sci, 65(10):29. PMCID: PMC11343002

Terao R, Lee TJ, Colasanti J, Pfeifer CW, Lin JB, Santeford A, Hase K, Yamaguchi S, Du D, Sohn BS, Sasaki Y, Yoshida M, Apte RS. 2024 LXR/CD38 activation drives cholesterol-induced macrophage senescence and neurodegeneration via NAD+ depletion. Cell Rep, 43(5):114102. PMCID: PMC11223747

Lin JB, Santeford A, Colasanti JJ, Lee Y, Shah AV, Wang TJ, Ruzycki PA, Apte RS. 2024 Targeting cell-type-specific, choroid-peripheral immune signaling to treat age-related macular degeneration. Cell Rep Med, 5(1):101353. PMCID: PMC10829736