Jeffrey Lotthammer

Program: Computational and Systems Biology

Current advisor: Alex Holehouse, PhD

Undergraduate university: Ohio State University-Columbus, 2020

Enrollment year: 2020

Research summary

Graduate publications
Ginell GM, Emenecker RJ, Lotthammer JM, Keeley AT, Plassmeyer SP, Razo N, Usher ET, Pelham JF, Holehouse AS. 2025 Sequence-based prediction of intermolecular interactions driven by disordered regions. Science, 388(6749)::eadq8381. PMCID:

Lotthammer JM, Holehouse AS. 2025 Disentangling Folding from Energetic Traps in Simulations of Disordered Proteins. J Chem Inf Model, 65(6):2897-910. PMCID:

Lotthammer JM, Ginell GM, Griffith D, Emenecker RJ, Holehouse AS. 2024 Direct prediction of intrinsically disordered protein conformational properties from sequences. Nat Metab, 21(3):465-76. PMCID: PMC10927563

Meller A, Lotthammer JM, Smith LG, Novak B, Lee LA, Kuhn CC, Greenberg L, Leinwand LA, Greenberg MJ, Bowman GR. 2023 Drug specificity and affinity are encoded in the probability of cryptic pocket opening in myosin motor domains. Elife, 12():e83602. PMCID: PMC9995120

Meller A, Ward M, Borowsky J, Kshirsagar M, Lotthammer JM, Oviedo F, Ferres JL, Bowman GR. 2023 Predicting locations of cryptic pockets from single protein structures using the PocketMiner graph neural network. Nat Commun, 14(1):1177. PMCID: PMC9977097

Lee LA, Barrick SK, Meller A, Walklate J, Lotthammer JM, Tay JW, Stump WT, Bowman G, Geeves MA, Greenberg MJ, Leinwand LA. 2023 Functional divergence of the sarcomeric myosin, MYH7b, supports species-specific biological roles. J Biol Chem, 299(1):102657. PMCID: PMC9800208