Jenna Eschbach

Program: Plant and Microbial Biosciences

Current advisor: Sebla B. Kutluay, PhD

Undergraduate university: Truman State University, 2017

Enrollment year: 2019

Research summary
Investigating the role of the FRA1 kinesin during xylem vessel differentiation

The processes of secondary cell wall formation and xylem vessel differentiation remain incompletely understood. Fragile Fiber1 (FRA1), a plant kinesin, is believed to contribute to the production of primary and secondary cell walls. Using a fra1-5 knockout mutant, I am characterizing the localization and motility of the FRA1 kinesin during xylem vessel differentiation.

Graduate publications
Shema Mugisha C, Dinh T, Kumar A, Tenneti K, Eschbach JE, Davis K, Gifford R, Kvaratskhelia M, Kutluay SB. 2022 Emergence of Compensatory Mutations Reveals the Importance of Electrostatic Interactions between HIV-1 Integrase and Genomic RNA. mBio, ():e0043122.

Puray-Chavez M, LaPak KM, Schrank TP, Elliott JL, Bhatt DP, Agajanian MJ, Jasuja R, Lawson DQ, Davis K, Rothlauf PW, Liu Z, Jo H, Lee N, Tenneti K, Eschbach JE, Puray-Chavez M, LaPak KM, Schrank TP, Elliott JL, Bhatt DP, Agajanian MJ, Jasuja R, Lawson DQ, Davis K, Rothlauf PW, Liu Z, Jo H, Lee N, Tenneti K, Eschbach JE, Shema Mugisha C, Cousins EM, Cloer EW, Vuong HR, VanBlargan LA, Bailey AL, Gilchuk P, Crowe JE Jr, Diamond MS, Hayes DN, Whelan SPJ, Horani A, Brody SL, Goldfarb D, Major MB, Kutluay S. 2021 Systematic analysis of SARS-CoV-2 infection of an ACE2-negative human airway cell. Cell Rep, 36(2):109364.

Eschbach JE, Elliott JL, Li W, Zadrozny KK, Davis K, Mohammed SJ, Lawson DQ, Pornillos O, Engelman AN, Kutluay SB. 2020 Capsid lattice destabilization leads to premature loss of the viral genome and integrase enzyme during HIV-1 infection. J Virol, 95(2):e00984-20.