Jie Chen

Program: Molecular Genetics and Genomics

Current advisor: David G. DeNardo, PhD

Undergraduate university: Zhejiang University, 2022

Enrollment year: 2023

Research summary
Prime radiation therapy(RT)-induced anti-tumor immunity in PDAC

My current projects are to define key tumor-intrinsic and tumor-extrinsic (conventional dendritic cells) factors that regulate immune surveillance during RT in pancreatic ductal adenocarcinoma.

Graduate publications
Situ K, Duan H, Godin SK, Yang J, McCloskey GQ, Naeem B, Gillis MK, Zeb MH, Salhotra S, Rawal P, Patel N, Mouliere SK, Chen J, Békési A, Pálinkás HL, Venkatesan S, Green AM, Birkbak NJ, Vértessy BG, Swanton C, Pathania S. 2025 BRCA2 deficiency and replication stress drive APOBEC3-Mediated genomic instability. Nat Commun, 16(1):9544. PMCID: PMC12572151