Jing Chen

Program: Immunology

Current advisor: Kenneth M. Murphy, MD, PhD

Undergraduate university: New York University, 2018

Enrollment year: 2018

Research summary
Dendritic Cell Development

Dendritic cells (DCs) functions to bridge innate and adaptive immunity by mediating the activity of various effector cells. The two branches of DCs consists of plasmacytoid DCs (pDCs) and classical DCs (cDCs), of which can be further subdivided into cDC1s and cDC2s. cDC1s are uniquely important in response against intracellular pathogens and tumors due to their ability to cross-present antigens. My work in the Murphy lab will seek to better understand DC development—specifically the molecular genetic circuitries and transcriptional requirements driving lineage-differentiation.

Graduate publications
Kim S, Chen J, Ou F, Liu TT, Jo S, Gillanders WE, Murphy TL, Murphy KM. 2024 Transcription factor C/EBPα is required for the development of Ly6Chi monocytes but not Ly6Clo monocytes. Proc Natl Acad Sci USA, 121(15):e2315659121. PMCID: PMC11009651

Ferris ST, Liu T, Chen J, Ohara RA, Ou F, Wu R, Kim S, Murphy TL, Murphy KM. 2023 WDFY4 deficiency in NOD mice ameliorates autoimmune diabetes and insulitis. Proc Natl Acad Sci USA, 120(13):e2219956120. PMCID: PMC10068798

Kim S, Chen J, Jo S, Ou F, Ferris ST, Liu TT, Ohara RA, Anderson DA, Wu R, Chen MY, Gillanders WE, Gillanders WE, Murphy TL, Murphy KM. 2023 IL-6 selectively suppresses cDC1 specification via C/EBPβ. J Exp Med, 220(10):e20221757. PMCID: PMC10336151

Ferris ST, Ohara RA, Ou F, Wu R, Huang X, Kim S, Chen J, Liu TT, Schreiber RD, Murphy TL, Murphy KM. 2022 cDC1 vaccines drive tumor rejection by direct presentation independently of host cDC1. Cancer Immunol Res, 10(8):920-931

Huang X, Ferris ST, Kim S, Choudhary MNK, Belk JA, Fan C, Qi Y, Sudan R, Xia Y, Desai P, Chen J, Ly N, Shi Q, Bagadia P, Liu T, Guilliams M, Egawa T, Colonna M, Diamond MS, Murphy TL, Satpathy AT, Wang T, Murphy KM. 2021 Differential usage of transcriptional repressor Zeb2 enhancers distinguishes adult and embryonic hematopoiesis. Immunity, 54(7):1417-1432.e7. PMCID: PMC8282756