Joshua Tobin

MSTP in PhD Training

Program: Immunology

Current advisor: Megan A. Cooper, MD, PhD

Undergraduate university: Georgetown University, 2018

Enrollment year: 2019

Research summary
Novel primary immunodeficiency results in impaired B Cell memory

I study inborn errors of immunity and am currently investigating a family with an inherited specific antibody deficiency (SAD), in which they have normal antibody levels but deficiencies in forming antigen-specific antibodies in response to infection or vaccination. The mechanism behind specific antibody deficiency is poorly understood, and we hope that studying patients with inherited forms of SAD will unveil the molecular pathways involved in the pathogenesis of SAD.

Graduate publications
Mah-Som AY, Keppel MP, Tobin JM, Kolicheski A, Saucier N, Sexl V, French AR, Wagner JA, Fehniger TA, Cooper MA. 2021 Reliance on Cox10 and oxidative metabolism for antigen-specific NK cell expansion. Cell Rep, 35(9):109209. PMCID: PMC8229496