Juanru Guo

Program: Computational and Systems Biology

Current advisor: Robi Mitra, PhD

Undergraduate university: Tongji University, 2021

Enrollment year: 2021

Research summary
I develop computational and machine learning methods for spatial and single-cell multi-omics to better understand cellular organization, state, and response across biological systems.

Graduate publications
Boros BD, Gachechiladze MA, Guo J, Galloway DA, Mueller SM, Shabsovich M, Yen A, Chen X, Cammack AJ, Shen T, Mitra RD, Dougherty JD, Miller TM. 2026 Antecedent enhancer activity predicts future susceptibility to seizures in mice. Nat Commun, 17(1):300. PMCID: PMC12789462

Guo J, Sarafinovska S, Hagenson RA, Valentine MC, Chen DY, McCoy Iv WH, Dougherty JD, Mitra RD, Muegge BD. 2026 SMURF: soft-segmentation for single-cell reconstruction and topological analysis of spatial transcriptomic data. Nat Commun, 17(1):7990. PMCID: PMC13447825

Dixon EE, Wu H, Sulvarán-Guel E, Guo J, Humphreys BD. 2022 Spatially resolved transcriptomics and the kidney: many opportunities. Kidney Int, 102(3):482-91