Keigo Takahashi

Program: Molecular Genetics and Genomics

Current advisor: Jonathan Cooper, PhD

Undergraduate university: Keio University, 2015

Enrollment year: 2018

Research summary
Cell-type-specific contribution to the pathogenesis of CLN2 disease or classic late infantile neuronal ceroid lipofuscinosis

Graduate publications
Sleat DE, Banach-Petrosky W, Larrimore KE, Nemtsova Y, Wiseman JA, Najafi A, Johnson D, Poole TA, Takahashi K, Cooper JD, Lobel P. 2023 A mouse mutant deficient in both neuronal ceroid lipofuscinosis-associated proteins CLN3 and TPP1. J Inherit Metab Dis, 46(4):720-34. PMCID:

Takahashi K, Nelvagal HR, Lange J, Cooper JD. 2022 Glial Dysfunction and Its Contribution to the Pathogenesis of the Neuronal Ceroid Lipofuscinoses. Front Neurol, 13():886567

Takahashi K, Le SQ, Kan SH, Jansen MJ, Dickson PI, Cooper JD. 2022 Neuropathology of murine Sanfilippo D syndrome. Mol Gen Genet, 134(4):323-29. PMCID:

Nelvagal HR, Lange J, Takahashi K, Tarczyluk-Wells MA, Cooper JD. 2020 Pathomechanisms in the neuronal ceroid lipofuscinoses. Biochim Biophys Acta Mol Basis Dis, 1866(9):E165570

Li G, Khandekar A, Yin T, Hicks SC, Guo Q, Takahashi K, Lipovsky CE, Brumback BD, Rao PK, Weinheimer CJ, Rentschler SL. 2018 Differential Wnt-mediated programming and arrhythmogenesis in right versus left ventricles. J Mol Cell Cardiol, 123():92-107. PMCID: PMC6200419