Khai Nguyen
MSTP in PhD Training
Program: Immunology
Current advisor: Marco Colonna, MD
Undergraduate university: Earlham College, 2020
Enrollment year: 2020
Research summary
Homeostatic and pathologic roles of B-cells in the meninges.
My research in the Colonna lab focuses on epigenetic mechanisms underlying macrophage development and function. We are particularly interested in microglia, and in the mechanisms that regulate Trem2 expression.
Graduate publications
Brioschi S, Belk JA, Peng V, Molgora M, Rodrigues PF, Nguyen KM, Wang S, Du S, Wang WL, Grajales-Reyes GE, Ponce JM, Yuede CM, Li Q, Baer JM, DeNardo DG, Gilfillan S, Cella M, Satpathy AT, Colonna M. 2023 A Cre-deleter specific for embryo-derived brain macrophages reveals distinct features of microglia and border macrophages. Immunity, 56(5):1027-1045.e8. PMCID: PMC10175109
Ver Heul A, Fredman A, Trier A, Tamari M, Nguyen K, Kim B. 2022 Type 2 inflammation drives transcriptional remodeling of itch-sensory neurons. J Allergy Clin Immunol, 149(2):AB221
Wang S, Sudan R, Peng V, Zhou Y, Du S, Yuede CM, Lei T, Hou J, Cai Z, Cella M, Nguyen K, Poliani PL, Beatty WL, Chen Y, Cao S, Lin K, Rodrigues C, Ellebedy AH, Gilfillan S, Brown GD, Holtzman DM, Brioschi S, Colonna M. 2022 TREM2 drives microglia response to amyloid-β via SYK-dependent and -independent pathways. Cell, 185(22):4153-4169.e19. PMCID: PMC9625082