Khai Nguyen

MSTP in PhD Training

Program: Immunology

Current advisor: Marco Colonna, MD

Undergraduate university: Earlham College, 2020

Enrollment year: 2020

Research summary
Homeostatic and pathologic roles of B-cells in the meninges.

My research in the Colonna lab focuses on epigenetic mechanisms underlying macrophage development and function. We are particularly interested in microglia, and in the mechanisms that regulate Trem2 expression.

Graduate publications
Brioschi S, Belk JA, Peng V, Molgora M, Rodrigues PF, Nguyen KM, Wang S, Du S, Wang WL, Grajales-Reyes GE, Ponce JM, Yuede CM, Li Q, Baer JM, DeNardo DG, Gilfillan S, Cella M, Satpathy AT, Colonna M. 2023 A Cre-deleter specific for embryo-derived brain macrophages reveals distinct features of microglia and border macrophages. Immunity, 56(5):1027-1045.e8. PMCID: PMC10175109

Ver Heul A, Fredman A, Trier A, Tamari M, Nguyen K, Kim B. 2022 Type 2 inflammation drives transcriptional remodeling of itch-sensory neurons. J Allergy Clin Immunol, 149(2):AB221

Wang S, Sudan R, Peng V, Zhou Y, Du S, Yuede CM, Lei T, Hou J, Cai Z, Cella M, Nguyen K, Poliani PL, Beatty WL, Chen Y, Cao S, Lin K, Rodrigues C, Ellebedy AH, Gilfillan S, Brown GD, Holtzman DM, Brioschi S, Colonna M. 2022 TREM2 drives microglia response to amyloid-β via SYK-dependent and -independent pathways. Cell, 185(22):4153-4169.e19. PMCID: PMC9625082