Kyle McGeehan

Program: Cancer Biology

Current advisor: Alexander Stegh, PhD

Undergraduate university: University of Notre Dame, 2020

Enrollment year: 2022

Research summary
I am analyzing the effects of laser ablation on the immune landscape in the Glioblastoma tumor microenvironment.

Glioblastoma (GBM) is the most common malignant, primary brain tumor of the central nervous system and remains an incurable disease with a median survival of about 15 months. Despite recent advances in immunotherapy in other types of cancer, no such clinical benefit exists for patients with GBM. My research project is focused on investigating the resulting impact that laser interstitial thermal therapy has on the GBM immune microenvironment in hopes of leveraging laser ablation with immunotherapy for a potential cure.

Graduate publications
Pugazenthi S, Patel B, English CW, Leidig WA, McGeehan KP, McCornack CR, Mok S, Anzaldua-Campos M, Nouri SH, Roberts K, Chatrath A, Khan A, Gadot R, Yano H, Klisch TJ, Harmanci AS, Patel AJ, Kim AH. 2024 Multiomic and clinical analysis of multiply recurrent meningiomas reveals risk factors, underlying biology, and insights into evolution. Sci Adv, 10(43):eadn4419. PMCID: PMC11498213