Logan Brase

Program: Human and Statistical Genetics

Current advisor: Oscar M. Harari, PhD

Undergraduate university: Brigham Young University, 2018

Enrollment year: 2018

Research summary
I use single-nucleus RNA-seq to evaluate how biological sex and genetic variants associated with Alzheimer disease influence gene expression in the brain

Graduate publications
Brase L, You SF, D’Oliveira Albanus R, Del-Aguila JL, Dai Y, Novotny BC, Soriano-Tarraga C, Dykstra T, Fernandez MV, Budde JP, Bergmann K, Morris JC, Bateman RJ, Perrin RJ, McDade E, Xiong C, Goate AM, Farlow M; Dominantly Inherited Alzheimer Network (DIAN); Sutherland GT, Kipnis J, Karch CM, Benitez BA, Harari O. 2023 Single-nucleus RNA-sequencing of autosomal dominant Alzheimer disease and risk variant carriers. Nat Commun, 14(1):2314. PMCID: PMC10121712

Sheehan PW, Nadarajah CJ, Kanan MF, Patterson JN, Novotny B, Lawrence JH, King MW, Brase L, Inman CE, Yuede CM, Lee J, Patel TK, Harari O, Benitez BA, Davis AA, Musiek ES. 2023 An astrocyte BMAL1-BAG3 axis protects against alpha-synuclein and tau pathology. Neuron, ():Online ahead of print. PMCID:

Gratuze M, Schlachetzki JCM, D’Oliveira Albanus R, Jain N, Novotny B, Brase L, Rodriguez L, Mansel C, Kipnis M, O’Brien S, Pasillas MP, Lee C, Manis M, Colonna M, Harari O, Glass CK, Ulrich JD, Holtzman DM. 2022 TREM2-independent microgliosis promotes tau-mediated neurodegeneration in the presence of ApoE4. Neuron, 111(2):202-219.e7. PMCID: PMC9852006

Da Mesquita S, Papadopoulos Z, Dykstra T, Brase L, Farias FG, Wall M, Jiang H, Kodira CD, de Lima KA, Herz J, Louveau A, Goldman DH, Salvador AF, Onengut-Gumuscu S, Farber E, Dabhi N, Kennedy T, Milam MG, Baker W, Smirnov I, Rich SS; Dominantly Inherited Alzheimer Network, Benitez BA, Karch CM, Perrin RJ, Farlow M, Chhatwal JP, Holtzman DM, Cruchaga C, Harari O, Kipnis J. 2021 Meningeal lymphatics affect microglia responses and anti-Aβ immunotherapy. Nature, 593(7858): 255-60. PMCID: PMC8817786