Matt Jansen

Program: Neurosciences

Current advisor: Tamara Hershey, PhD

Undergraduate university: University of Notre Dame, 2020

Enrollment year: 2023

Research summary
Determining the relationship between general/regional adiposity, inflammatory diet, and neuroinflammation in older adults using advanced diffusion MRI techniques

Graduate publications
Jansen MJ, Lugar HM, Brown CM, Tang AF, Oiknine LJ, Chen L, Koller JM, Gordon BA, Marshall BA, Urano F, Hershey T. 2026 Neurofilament light chain but not glial fibrillary acidic protein serum levels are elevated in Wolfram syndrome. Front Neurosci, 20():1805916

Ziólkowska EA, Williams LL, Jansen MJ, Wang SH, Eultgen EM, Sharma J, Sardiello M, Bradley RP, Whiteman IT, Sands MS, Heuckeroth RO, Cooper JD. 2025 Enteric nervous system degeneration in human and murine CLN3 disease, is ameliorated by gene therapy in mice. Acta Neuropathol Commun, 13(1):260. PMCID: PMC12751165

Ziólkowska EA, Jansen MJ, Williams LL, Wang SH, Eultgen EM, Takahashi K, Le SQ, Nelvagal HR, Sharma J, Sardiello M, DeBosch BJ, Dickson PI, Anderson JB, Sax SE, Wright CM, Bradley RP, Whiteman IT, Makita T, Grider JR, Sands MS, Heuckeroth RO, Cooper JD. 2025 Gene therapy ameliorates bowel dysmotility and enteric neuron degeneration and extends survival in lysosomal storage disorder mouse models. Sci Transl Med, 17(781):eadj1445. PMCID: PMC12087356

Ziólkowska EA, Jablonka-Shariff A, Williams LL, Jansen MJ, Wang SH, Eultgen EM, Wood MD, Hunter DA, Sharma J, Sardiello M, Reese R, Pestronk A, Sands MS, Snyder-Warwick AK, Cooper JD. 2025 Gene therapy ameliorates neuromuscular pathology in CLN3 disease. Acta Neuropathol Commun, 13(1):160. PMCID: PMC12285172

Takahashi K, Le SQ, Kan SH, Jansen MJ, Dickson PI, Cooper JD. 2021 Neuropathology of murine Sanfilippo D syndrome. Mol Gen Genet, 134(4):323-29. PMCID: