Melvin King

Program: Neurosciences

Current advisor: Erik S. Musiek, MD, PhD

Undergraduate university: Dartmouth College, 2016

Enrollment year: 2018

Research summary
Examination of behavioral circadian regulation of amyloid beta pathology in mouse models

Graduate publications
Lawrence JH, Patel A, King MW, Nadarajah CJ, Daneman R, Musiek ES. 2024 Microglia drive diurnal variation in susceptibility to inflammatory blood-brain barrier breakdown. JCI Insight, 9(21)::e180081. PMCID: PMC11601573

Lee J, Dimitry JM, Song JH, Son M, Sheehan PW, King MW, Travis Tabor G, Goo YA, Lazar MA, Petrucelli L, Musiek ES. 2023 Microglial REV-ERBα regulates inflammation and lipid droplet formation to drive tauopathy in male mice. Nat Commun, 14(1):5197. PMCID: PMC10457319

King MW, Chen Y, Musiek ES. 2023 Time-restricted feeding and Alzheimer’s disease: you are when you eat. Trends Mol Med, 29(12):974-75. PMCID: PMC10842495

Sheehan PW, Nadarajah CJ, Kanan MF, Patterson JN, Novotny B, Lawrence JH, King MW, Brase L, Inman CE, Yuede CM, Lee J, Patel TK, Harari O, Benitez BA, Davis AA, Musiek ES. 2023 An astrocyte BMAL1-BAG3 axis protects against alpha-synuclein and tau pathology. Neuron, 111(15):2383-2398.e7. PMCID: PMC10524543

McKee CA, Polino AJ, King MW, Musiek ES. 2023 Circadian clock protein BMAL1 broadly influences autophagy and endolysosomal function in astrocytes. Proc Natl Acad Sci USA, 120(20):e2220551120. PMCID: PMC10194014

Mahali S, Martinez R, King M, Verbeck A, Harari O, Benitez BA, Horie K, Sato C, Temple S, Karch CM. 2022 Defective proteostasis in induced pluripotent stem cell models of frontotemporal lobar degeneration. Transl Psychiatry, 12(1):508. PMCID: PMC9734180

Lananna BV, McKee CA, King MW, Del-Aguila JL, Dimitry JM, Farias FHG, Nadarajah CJ, Xiong DD, Guo C, Cammack AJ, Elias JA, Zhang J, Cruchaga C, Musiek ES. 2020 Chi3l1/YKL-40 is controlled by the astrocyte circadian clock and regulates neuroinflammation and Alzheimer’s disease pathogenesis. Sci Transl Med, 12(574):eaax3519. PMCID: PMC7808313