People

Program: Computational and Systems Biology

Graduation Year: 2018

Thesis Advisor: Joshua Swamidass

Thesis Title: Modeling the Bioactivation and Subsequent Reactivity of Drugs

Program: Molecular Cell Biology

Graduation Year: 2016

Thesis Advisor: Andrew Yoo

Thesis Title: Maintenance of Age in Reprogrammed Human Neurons

Program: Biochemistry

Graduation Year: 2012

Thesis Advisor: Helen M. Piwnica-Worms

Thesis Title: Regulation of CHK1 Stability by the Ubiquitin Proteasome System

Program: Molecular Cell Biology

Graduation Year: 2009

Thesis Advisor: David M. Ornitz

Thesis Title: Wnt/b-Catenin Regulation of Pharyngeal Arch Development and DiGeorge Syndrome

Program: Developmental Biology

Graduation Year: 2010

Thesis Advisor: Jason C. Mills

Thesis Title: Transcriptional Regulation of Zymogenic (Chief) Cell Differentiation and Maintenance in Adult Mouse Stomach

Program: Molecular Microbiology and Microbial Pathogenesis

Current advisor: Daved H. Fremont, PhD

Undergraduate university: University of California-San Diego, 2015

Program affiliation
Molecular Microbiology and Microbial Pathogenesis
Plant and Microbial Biosciences
Biochemistry Biophysics and Structural Biology
Molecular Cell Biology

Research summary
Interdisciplinary approach combining genetics, genomics, biochemistry, structural biology, high-resolution imaging, animal models, clinical studies and combinatorial chemistry to determine key aspects of bacterial pathogenesis and apply our knowledge to development of new therapeutics.

Key words
antibiotic-sparing therapeutics, host-pathogen interactions, bacterial pathogenesis, drug and vaccine development, multi-drug resistant E. coli, MRSA, Enterococcus, Acinetobacter, Klebsiella, urinary tract infections (UTI)

Program: Molecular Genetics and Genomics

Graduation Year: 2009

Thesis Advisor: Stephen L. Johnson

Thesis Title: The role of kit ligand in Zebrafish Melanocyte Ontogeny and Regeneration

Program affiliation
Developmental Regenerative and Stem Cell Biology
Computational and Systems Biology

Research summary
Define cell hierarchies in kidney injury and repair and thereby identify the critical cell types in kidney repair and fibrosis

Key words
Stem cells, regenerative medicine, scRNA-seq, scATAC-seq, spatial transcriptomics, fibrosis, gene editing, iPS cells

Program: Human and Statistical Genetics

Graduation Year: 2018

Thesis Advisor: Malachi Griffith

Thesis Title: Sequence analysis methods for the design of cancer vaccines that target tumor-specific mutant antigens (neoantigens)