Siling Du
Program: Immunology
Current advisor: Jonathan Kipnis, PhD
Undergraduate university: Nankai University, 2020
Enrollment year: 2020
Research summary
Dura mater immunity in neurodegeneration.
Graduate publications
Kim K, Abramishvili D, Du S, Papadopoulos Z, Cao J, Herz J, Smirnov I, Thomas JL, Colonna M, Kipnis J. 2025 Meningeal lymphatics-microglia axis regulates synaptic physiology. Cell, 188(10):2705-2719.e23. PMCID: PMC12086007
Smyth LCD, Xu D, Okar SV, Dykstra T, Rustenhoven J, Papadopoulos Z, Bhasiin K, Kim MW, Drieu A, Mamuladze T, Blackburn S, Gu X, Gaitán MI, Nair G, Storck SE, Du S, White MA, Bayguinov P, Smirnov I, Dikranian K, Reich DS, Kipnis J. 2024 Identification of direct connections between the dura and the brain. Nature, 627(8002):165-73. PMCID: PMC11254388
Gao W, Kim MW, Dykstra T, Du S, Boskovic P, Lichti CF, Ruiz-Cardozo MA, Gu X, Weizman Shapira T, Rustenhoven J, Molina C, Smirnov I, Merbl Y, Ray WZ, Kipnis J. 2024 Engineered T cell therapy for central nervous system injury. Nature, 634(8034):693-701. PMCID:
Ou F, Liu TT, Desai P, Ferris ST, Kim S, Shen H, Ohara RA, Jo S, Chen J, Postoak JL, Du S, Diamond MS, Murphy TL, Murphy KM. 2024 Optimization of the Irf8 +32-kb enhancer disrupts dendritic cell lineage segregation. Nat Immunol, 25(11):2043-56. PMCID:
Rustenhoven J, Pavlou G, Storck SE, Dykstra T, Du S, Wan Z, Quintero D, Scallan JP, Smirnov I, Kamm RD, Kipnis J. 2023 Age-related alterations in meningeal immunity drive impaired CNS lymphatic drainage. J Exp Med, 220(7):e20221929. PMCID: PMC10083715
Drieu A, Du S, Storck SE, Rustenhoven J, Papadopoulos Z, Dykstra T, Zhong F, Kim K, Blackburn S, Mamuladze T, Harari O, Karch CM, Bateman RJ, Perrin R, Farlow M, Chhatwal J; Dominantly Inherited Alzheimer Network; Hu S, Randolph GJ, Smirnov I, Kipnis J. 2022 Parenchymal border macrophages regulate the flow dynamics of the cerebrospinal fluid. Nature, 611(7936):585-593. PMCID: PMC9899827