Sofia Smith

Program: Molecular Genetics and Genomics

Current advisor: George P. Souroullas, PhD

Undergraduate university: University of Texas-Austin, 2020

Enrollment year: 2020

Research summary
My research aims to identify how gain-of-function events in EZH2, a histone methyltransferase, contribute to the development of mature B cell lymphoma.

Graduate publications
Zimmerman SM, Suh E, Smith SR, Souroullas GP. 2024 Stat3-mediated Atg7 expression regulates anti-tumor immunity in mouse melanoma. Cancer Immunol Immunother, 73(11):218. PMCID: 39235510

Zimmerman SM, Nixon SJ, Chen PY, Raj L, Smith SR, Paolini RL, Lin PN, Souroullas G. 2023 Ezh2Y641F mutations co-operate with Stat3 to regulate MHC class I antigen processing and alter the tumor immune response in melanoma. Oncogene, 41(46):4933-93. PMCID: PMC9669177