Steven Yang

MSTP in PhD Training

Program: Immunology

Current advisor: Kory J. Lavine, MD, PhD

Undergraduate university: University of Pennsylvania, 2015

Enrollment year: 2021

Research summary
Mechanisms of CAR T therapy in cardiac fibrosis

Fibroblast activation protein has been shown to be elevated in fibroblasts in failing, but not control, hearts in both humans and mice. Chimeric antigen receptor T cells may be directed against fibroblast activation protein and it has been shown that these CAR T cells can prevent fibrosis and rescue systolic function. My project seeks to understand how these engineered T cells remodel the cardiac immune landscape and what effects these changes may have on preventing adverse cardiac remodeling and preserving cardiac function.

Graduate publications