Tony Yao

Program: Immunology

Current advisor: Naresha Saligrama, PhD

Undergraduate university: University of Western Ontario, 2019

Enrollment year: 2022

Research summary
Mechanistic basis of immune-related toxicities caused by checkpoint inhibition

Enhanced anti-tumor responses elicited by checkpoint inhibitors are often accompanied by immune toxicities that evince a break in self-tolerance. We seek to delineate the pathways that causally relate these phenomena.

Graduate publications
Wong P, Foltz JA, Chang L, Neal CC, Yao T, Cubitt CC, Tran J, Kersting-Schadek S, Palakurty SX, Jaeger N, Russler-Germain DA, Marin ND, Gang M, Wagner JA, Zhou AY, Jacobs MT, Foster M, Schappe T, Marsala L, McClain E, Pence P, Becker-Hapak M, Fisk B, Petti AA, Griffith OL, Griffith M, Berrien-Elliott MM, Fehniger TA. 2023 T-BET and EOMES sustain mature human NK cell identity and anti-tumor function. J Clin Invest, 133(13)::e162530. PMCID: PMC10313375