Computational and Systems Biology

Program affiliation
Biochemistry Biophysics and Structural Biology
Cancer Biology
Computational and Systems Biology
Molecular Cell Biology

Research summary

Key words

Program affiliation
Immunology
Computational and Systems Biology
Biochemistry Biophysics and Structural Biology

Research summary
Systems immunology using high-throughput next-generation sequencing in conjunction with mathematical and statistical modeling approaches rooted in statistical physics

Key words
systems immunology, systems biology, computational biology, RNA-seq

Program affiliation
Molecular Microbiology and Microbial Pathogenesis
Molecular Genetics and Genomics
Immunology
Computational and Systems Biology

Research summary
Defining the mechanisms behind and effects of the interactions between commensal bacteria, pathogens and innate immunity

Key words
microbiota, infection, pathogen, microbiome, virus, interferon, immunity

Program affiliation
Plant and Microbial Biosciences
Computational and Systems Biology

Research summary
We use quantitative genetics and high throughput phenotyping approaches to understand how plants adapt to their environment

Key words
Ionomics, Genetics, Genomics, Gene by Environment Interactions, Plants

Program affiliation
Biomedical Informatics and Data Science
Molecular Genetics and Genomics
Computational and Systems Biology
Neurosciences

Research summary
Our research is dedicated to understanding the genetics of Alzheimer’s disease and related disorders, employing bioinformatic tools and a big-data approach that integrates genetics, multi-omics, brain imaging, and clinical data.

Key words
Genetics, Multi-Omics, Bioinformatics, Neurodegeneration, Alzheimer's disease

Program affiliation
Neurosciences
Biomedical Informatics and Data Science
Computational and Systems Biology

Research summary
Computational neuroimaging using big data to study brain organization and mental health

Key words
mental health, fMRI, connectivity, big data, psychiatry, computational models

Program affiliation
Human and Statistical Genetics
Computational and Systems Biology
Cancer Biology

Research summary
The interplay between inherited genetic variation, environmental factors, and acquired mutations in shaping the earliest stages of carcinogenesis

Key words
cancer, genetics, computational biology, genetic epidemiology

Program affiliation
Plant and Microbial Biosciences
Molecular Genetics and Genomics
Molecular Microbiology and Microbial Pathogenesis
Computational and Systems Biology

Research summary
Microbial metabolisms and their influence on biogeochemical cycling

Key words

Program affiliation
Computational and Systems Biology
Human and Statistical Genetics
Molecular Genetics and Genomics

Research summary
Computational genomics, human genetics, systems biology, transcriptional regulatory networks

Key words
computational biology, systems biology, regulatory circuits, computational genomics, multi-omics integration, human genetics

Program affiliation
Computational and Systems Biology
Molecular Genetics and Genomics

Research summary
Developing algorithms and architectures for large-scale biosequence comparison, genome annotation, and metagenomics

Key words
annotation, bioinformatics, computational biology, genome analysis, metagenomics