Faculty

Program affiliation
Molecular Genetics and Genomics
Developmental Regenerative and Stem Cell Biology
Neurosciences

Research summary
Molecular mechanisms regulating photoreceptor gene expression in healthy and diseased retinas

Key words
Gene expression regulation, transcription factors, epigenetic regulators, photoreceptor development and degeneration, mouse models, gene therapy

Program affiliation
Neurosciences
Molecular Cell Biology
Biochemistry Biophysics and Structural Biology
Molecular Genetics and Genomics
Computational and Systems Biology

Research summary
Understanding the function of neuromodulators and sleep through the spatiotemporal dynamics of molecular signals

Key words
neuromodulator, sleep, dynamics, sensors, actuators, signaling, G protein coupled receptors, imaging, microscopy, learning, plasticity, engineering

Program affiliation
Molecular Genetics and Genomics
Biochemistry Biophysics and Structural Biology
Molecular Cell Biology

Research summary
Understanding the molecular mechanisms of primary nephrotic syndrome (NS)

Key words

Program affiliation
Biochemistry Biophysics and Structural Biology
Neurosciences
Molecular Cell Biology

Research summary
I am interested in the structure and function of neuronal ligand-gated ion channels, and the mechanism of channel modulation by endogenous lipids or exogenous drugs such as general anesthetics.

Key words

Program affiliation
Molecular Genetics and Genomics
Cancer Biology
Immunology
Developmental Regenerative and Stem Cell Biology

Research summary
Cancer stem cells, oncolytic viruses, and functional genomics of brain tumors

Key words
Cancer stem cells, oncolytic viruses, and functional genomics of brain tumors

Program affiliation
Neurosciences
Biochemistry Biophysics and Structural Biology

Research summary
The interface between systems and control engineering, neuroscience and neural medicine

Key words
Control of neural dynamics; Biophysical modeling of multiscale brain networks;

Program affiliation
Molecular Cell Biology
Immunology
Biochemistry Biophysics and Structural Biology

Research summary
Understanding the mechanism mediating intravascular cell-cell interactions and vascular occlusion under thromboinflammatory conditions, including thrombosis, ischemia/reperfusion injury, and sickle cell disease

Key words
Platelet, Neutrophil, Thrombosis, Inflammation, Sickle Cell Disease, Intravital microscopy

Program affiliation
Immunology
Molecular Cell Biology
Cancer Biology

Research summary
Understanding T cells and immunoregulatory networks in GvHD and GvL for the treatment of hematopoietic malignancies.

Key words
graft-versus-host disease (GvHD), graft-versus-leukemia (GvL), JAK-STAT, immune cell trafficking, transplant immunology, CRISPR/Cas9

Program affiliation
Developmental Regenerative and Stem Cell Biology
Immunology
Cancer Biology
Molecular Cell Biology

Research summary
Angioimmune interface in development, tissue regeneration, and cancer

Key words
Cell fate, transcription factors, hematopoiesis, vascular, development, regeneration, stem cells, tumor angiogenesis, tumor immunity

Program affiliation
Molecular Cell Biology
Biochemistry Biophysics and Structural Biology

Research summary
Our current research focuses on delineating the cellular, molecular, and metabolic processes involved in the development of fibrotic disorders such as Idiopathic pulmonary fibrosis (IPF) and how these metabolic adaptations may in turn be targeted therapeutically for IPF.

Key words
Idiopathic pulmonary fibrosis (IPF), metabolic networks, targetable mechanisms driving fibroblast function and fibrosis