Faculty

Program affiliation
Neurosciences

Research summary
Leveraging synaptic physiology to treat addiction and affective symptoms of pain

Key words
electrophysiology, deep brain stimulation, dopamine, basal ganglia, reward and aversion, addiction, genetics, pharmacology, optogenetics, pain

Program affiliation
Human and Statistical Genetics
Computational and Systems Biology
Molecular Genetics and Genomics

Research summary
Genetic variation in the variable response to pharmacologic treatment (i.e. Pharmacogenomics) of cardiovascular disease; specifically individuals with both diabetes mellitus and coronary artery disease.

Key words
cardiovascular disease, diabetes melitus, genotype, genetic variation

Program affiliation
Molecular Cell Biology
Biochemistry Biophysics and Structural Biology

Research summary
Understanding extracellular vesicle (EV)-mediated signaling during homeostatic and pathologic metabolic regulation

Key words

Program affiliation
Biochemistry Biophysics and Structural Biology
Developmental Regenerative and Stem Cell Biology
Molecular Cell Biology

Research summary
Structure and function of surfactant protein D (SP-D)

Key words
biochemistry, carbohydrate, gene expression, immunology, lipids

Program affiliation
Human and Statistical Genetics
Neurosciences
Biomedical Informatics and Data Science
Molecular Genetics and Genomics

Research summary
The goal of my lab is to understand the biology of neurodegeneration by using high-dimensional omic data and functional genomic approaches.

Key words
Neurodegeneration, Alzheimer, genetics, genomics, proteomics, system biology, molecular phenotyping, functional genomics

Program affiliation
Biochemistry Biophysics and Structural Biology
Neurosciences

Research summary
Molecular basis of bioelectricity and related diseases in nervous and cardiovascular systems; ion channel function and modulation; discovery of drugs that target ion channels

Key words
allosteric regulation, calcium, drug mechanisms, epilepsy, ion channel, structure-function analysis

Program affiliation
Neurosciences

Research summary
Non-invasive optical measurements for both functional- and molecular- biological imaging

Key words

Program affiliation
Molecular Microbiology and Microbial Pathogenesis
Molecular Genetics and Genomics
Immunology
Developmental Regenerative and Stem Cell Biology

Research summary
To address the central mandate of gene therapy we engineer adenovirus tropism to allow the achievement of effective gene delivery

Key words
Adenovirus, virotherapy, virus, cancer, gene therapy, vaccine

Program affiliation
Biochemistry Biophysics and Structural Biology
Neurosciences
Molecular Microbiology and Microbial Pathogenesis
Molecular Cell Biology

Research summary
My lab aims to establish the fundamental principles of intracellular physical chemistry and electrochemical functions of macromolecular complexes, and design synthetic proteins as therapeutics for condensate-dependent diseases.

Key words
molecular biology; physical chemistry; biochemistry; biophysics; synthetic biology; electrochemistry; phase transition; condensates

Program affiliation
Molecular Cell Biology
Developmental Regenerative and Stem Cell Biology
Molecular Genetics and Genomics

Research summary
My research aims to understand the lung vascular homeostasis and the pathogenesis of pulmonary diseases using novel animal models, integrated pharmacological approaches, genome editing and single cell RNA-sequencing and spatial transcriptomics.

Key words
cardiovascular, lung, vascular, single cell, spatial transcriptomic