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Farshid Guilak, PhD

Mildred B. Simon Research Professor

Program affiliation
Developmental Regenerative and Stem Cell Biology
Molecular Cell Biology
Immunology

Research summary
Application of stem cells and mechanobiology in the onset, progression, and treatment of osteoarthritis and other joint diseases.

Key words
cartilage, obesity, osteoarthritis, mechanobiology, bioengineering, stem cells, iPSCs

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Christina Gurnett, MD, PhD

Professor

Program affiliation
Molecular Genetics and Genomics

Research summary
Gene discovery, variant interpretation using high-throughput functional assays

Key words
genetics, genomics, sequencing, exome, development, muscle, arthrogryposis, limb, scoliosis, clubfoot

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David Gutmann, MD, PhD

Donald O. Schnuck Family Professor

Program affiliation
Neurosciences
Cancer Biology
Molecular Genetics and Genomics
Developmental Regenerative and Stem Cell Biology

Research summary
Leveraging neurogenetic disorders to study normal brain development, cancer, and autism

Key words
pediatric brain cancer, brain development, neuroimmunology, cancer neuroscience, autism, hiPSC engineering, genetically engineered mice

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Carmen Halabi, MD, PhD

Associate Professor

Program affiliation
Developmental Regenerative and Stem Cell Biology
Molecular Cell Biology
Molecular Genetics and Genomics

Research summary
Understanding how the extracellular matrix (ECM) contributes to normal arterial development and how its disruptionleads to abnormal vascular development and disease

Key words
Vascular biology, extracellular matrix, elastin, aneurysms, hypertension

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Kathleen Hall, PhD

Professor

Program affiliation
Biochemistry Biophysics and Structural Biology

Research summary
We study RNA folding and RNA binding to proteins

Key words
RNA, NMR, RNA:protein interactions, fluorescence, thermodynamics

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Dennis Hallahan, MD

Professor and Head of the Department of Radiation Oncology

Program affiliation
Cancer Biology
Molecular Cell Biology

Research summary
The mechanisms of cell death in normal tissues during cancer therapy

Key words
cancer, cell death, drug delivery, radiation, signal transduction

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Gabriel Haller, PhD

Assistant Professor

Program affiliation
Human and Statistical Genetics
Molecular Genetics and Genomics
Computational and Systems Biology
Neurosciences

Research summary
Genetic underpinnings of neurological/neurosurgical disorders

Key words
rare variants, Chiari I malformation, human genetics, neurosurgery, Deep Mutation Scanning, Mutagenesis, Limb-girdle muscular dystrophy

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Claudia Han, PhD

Assistant Professor

Program affiliation
Immunology
Molecular Genetics and Genomics
Developmental Regenerative and Stem Cell Biology
Neurosciences

Research summary
The Han lab investigates microglia and brain macrophage phenotypes in neurodevelopmental and neurodegenerative contexts through the lens of epigenomics and transcriptomics. 

Key words
microglia, neurodevelopment, epigenetics, transcriptomics, neurodegeneration

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Edward Han, PhD

Assistant Professor

Program affiliation
Neurosciences

Research summary
Learning-related hippocampal network activation

Key words
Learning, memory, behavior, virtual reality, in vivo two-photon calcium imaging, in vivo electrophysiology, systems neuroscience

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Scott Handley, PhD

Professor

Program affiliation
Computational and Systems Biology
Molecular Microbiology and Microbial Pathogenesis
Immunology

Research summary

Key words