Faculty

Program affiliation
Immunology
Neurosciences
Molecular Genetics and Genomics
Molecular Cell Biology

Research summary
We study complex interactions between the immune and nervous systems in health and disease

Key words
Neuroimmunology; neuroscience; immunology; lymphatics; behavior; Alzheimer’s disease; neurodegeneration; glia; microglia; blood-brain barrier (BBB); meninges

Program affiliation
Immunology
Cancer Biology
Molecular Microbiology and Microbial Pathogenesis
Computational and Systems Biology

Research summary
understand the biology of different human dendritic cells and other myeloid cells as a key for manipulating immune responses in various disease conditions

Key words
Human Immunology, Dendritic Cells, Tumor Immunology, immune dysfunctions, Vaccines

Program affiliation
Neurosciences

Research summary
Synaptic function and plasticity, neural computations, neurodevelopmental diseases

Key words

Program affiliation
Developmental Regenerative and Stem Cell Biology
Molecular Genetics and Genomics
Molecular Cell Biology
Biochemistry Biophysics and Structural Biology

Research summary
organismal aging; zinc homeostasis and roles of zinc during cell differentiation.

Key words
aging, metals, zinc, development, sperm activation, signal transduction, homeostasis

Program affiliation
Molecular Cell Biology

Research summary
Intracellular protein trafficking, including targeting of acid hydrolases to lysosomes

Key words
intracellular trafficking, receptor, mannose 6-phosphate, lysosome

Program affiliation
Immunology
Molecular Microbiology and Microbial Pathogenesis
Computational and Systems Biology

Research summary
My lab works on the host immune response to Mycobacterium tuberculosis. We use mouse models that mimic key aspects of human disease to gain a mechanistic understanding of the host response allowing for the identification of novel targets for host-directed therapies.

Key words
Mycobacterium tuberculosis, innate immunology, macrophages, neutrophils, dendritic cells

Program affiliation
Neurosciences
Molecular Cell Biology

Research summary
Mechanisms of neurodegeneration in Parkinson`s disease and related disorders

Key words
lipid metabolism, mouse models, neurodegeneration, pathogenesis, phospholipase A2, Parkinson disease

Program affiliation
Biochemistry Biophysics and Structural Biology

Research summary
Quantitative cardiovascular physiology, mathematical modeling of systems physiology, imaging

Key words
biophysics, cardiology, cardiovascular physiology, echocardiography, imaging, mathematical modeling

Program affiliation
Cancer Biology
Molecular Genetics and Genomics
Molecular Cell Biology

Research summary
Our laboratory focuses on the fundamental issues of DNA repair and how they relate to cancer initiation, progression, and therapy responses.

Key words
DNA repair, DNA replication

Program affiliation
Plant and Microbial Biosciences
Molecular Microbiology and Microbial Pathogenesis

Research summary
Gene regulation and biogenesis of extracellular components in bacteria

Key words
bacteria, gene expression, protein structure, plant biosensors, cytochromes