Faculty
Susan Perlman, PhD
Associate Professor
- Email: perlmansusan@wustl.edu
Program affiliation
Neurosciences
Research summary
Key words
David Perlmutter, MD
Spencer T. and Ann W. Olin Distinguished Professor
- Email: perlmutterd@wustl.edu
Program affiliation
Molecular Cell Biology
Immunology
Molecular Genetics and Genomics
Research summary
Pathobiology of liver disease from accumulation and proteotoxicity of misfolded proteins in α1-antitrypsin deficiency; role of autophagy in biology and treatment of disorders caused by misfolded proteins
Key words
α1-antitrypsin deficiency, protein secretion, protein degradation, autophagy, proteostasis, autophagy enhancer drugs
Joel Perlmutter, MD
Professor
- Email: perlmutterjoel@wustl.edu
Program affiliation
Neurosciences
Research summary
Pharmacology, physiology and pathophysiology of basal ganglia and movement disorders
Key words
pathogenesis, neuroimaging, physiology, neurobiology, movement disorders, Parkinson disease, dystonia
Stephen Persaud, MD,PhD
Assistant Professor
- Email: persaud@wustl.edu
Program affiliation
Immunology
Developmental Regenerative and Stem Cell Biology
Cancer Biology
Research summary
Optimizing hematopoietic stem cell transplantation as definitive therapy for non-malignant blood diseases
Key words
sickle cell disease, hematopoietic stem cell transplantation, antibody-based immunotherapy, conditioning, JAK inhibitors, gene editing
Steven Petersen, PhD
Professor Emeritus
- Email: sep@wustl.edu
Program affiliation
General
Research summary
Behavioral and fMRI studies of attention and cognitive development
Key words
attention, language, development, behavior, imaging
Christine Pham, MD
G & EM Magness Professor
- Email: cpham@wustl.edu
Program affiliation
Immunology
Molecular Genetics and Genomics
Research summary
Immunity and autoimmunity in inflammatory diseases; nanotherapy in the treatment of inflammatory diseases
Key words
autoimmunity, inflammation, innate immunity, nanotechnology, protease
Benjamin Philip, PhD
Assistant Professor
- Email: bphilip@wustl.edu
Program affiliation
Neurosciences
Research summary
The interaction between hand dominance, brain lateralization, and rehabilitation following unilateral impairment such as stroke, amputation, or nerve injury
Key words
Jennifer Philips, MD, PhD
Theodore and Bertha Bryan Professor
- Email: philips.j.a@wustl.edu
Program affiliation
Molecular Microbiology and Microbial Pathogenesis
Immunology
Molecular Cell Biology
Research summary
Immune Evasion by Mycobacterium tuberculosis
Key words
tuberculosis, host-pathogen interactions, innate immunity, autophagy, lipid metabolism, phagosome maturation, antigen presentation, macrophage
Jennifer Phillips-Cremins, PhD
BJC Investigator and James S. McDonnell Professor
- Email: jennifer.cremins@wustl.edu
Program affiliation
Molecular Genetics and Genomics
Neurosciences
Computational and Systems Biology
Developmental Regenerative and Stem Cell Biology
Molecular Cell Biology
Research summary
The Cremins lab integrates molecular and computational biology to elucidate how the genome’s structure-function relationship influences synaptic plasticity and neurophysiology during memory encoding and consolidation and how this goes awry in intractable neurological disorders.
Key words
chromatin, neuroepigenetics, 3D genome, synaptic plasticity, Alzheimer's, repeat expansion disorders, chromatin-synapse communication, neural connectome, organoids
Marco Pignatelli, MD
Assistant Professor
- Email: marco.pignatelli@wustl.edu
Program affiliation
Neurosciences
Molecular Cell Biology
Research summary
Understanding the synaptic mechanisms by which emotional experiences lead to maladaptive plasticity and the impact of neurotherapeutic drugs on those maladaptive synaptic neuroadaptations
Key words
synaptic plasticity, Optogenetics, cell-type specific pharmacology, patch clamp electrophysiology, rapid-acting antidepressants, motivated behavior, drug addiction and affective disorders