Mentorship Certified

Program affiliation
Neurosciences

Research summary
Cellular mechanisms underlying our systems of sound and balance encoding in development, in maturity, and in pathology of hearing or vestibular function

Key words
cochlea, neurodegeneration, synapse, excitotoxicity, encoding sound

Program affiliation
Immunology

Research summary
My research interests are in the genetics of immune-mediated diseases and the fundamental mechanisms of immune cell activation, immune dysregulation, and immunological tolerance. My current work focuses on delineating the mechanisms underlying a monogenic syndrome of early-onset autoimmunity caused by gain-of-function (GOF) mutations in STAT3.

Key words
Immune dysregulation, inborn errors of immunity, Treg, STAT, Pediatric

Program affiliation
Neurosciences

Research summary
Development and use of advanced optical microscopy solutions for preclinical imaging studies in brain and beyond

Key words
optical microscopy, neuroimaging, biomedical optics, oxygenation, neurovascular coupling, cerebral energetics

Program affiliation
Cancer Biology
Molecular Genetics and Genomics
Molecular Cell Biology

Research summary
Long non-coding RNAs and RNA modifications in cancer metastasis and aggressive disease

Key words
Cancer metastasis, multiple myeloma, breast cancer, long non-coding RNAs, RNA modifications, genomics, advanced sequencing, epitranscriptomics

Program affiliation
Molecular Genetics and Genomics
Developmental Regenerative and Stem Cell Biology
Neurosciences

Research summary
Genetic analysis of neural and muscular development in the Drosophila embryo

Key words
development, neurobiology, cell signaling

Program affiliation
Developmental Regenerative and Stem Cell Biology

Research summary
Work in our lab focuses on the role of insulin resistance in human metabolic diseases. To accomplish this, we focus our efforts on patients with severe insulin resistance syndromes.

Key words
Insulin Resistance, Atypical Diabetes, Pediatric Endocrinology, FGF21, Fibroblast Growth factors

Program affiliation
Developmental Regenerative and Stem Cell Biology
Molecular Cell Biology
Molecular Genetics and Genomics
Biochemistry Biophysics and Structural Biology

Research summary
The Stratman lab is broadly interested in how blood vessels form and stabilize during development, and how changes in these processes affect tissue homeostasis and disease.

Key words
mechanobiology, vascular, endothelial cell, blood flow

Program affiliation
Molecular Microbiology and Microbial Pathogenesis
Biomedical Informatics and Data Science

Research summary
Infectious causes of cancer and chronic diseases

Key words

Program affiliation
Immunology
Molecular Cell Biology
Molecular Genetics and Genomics

Research summary
We investigate how the immune system maintains balance during healthy homeostasis, and when this balance is thrown off, how the dysregulated activities of the same immune cells cause immune diseases such as asthma, allergy and autoimmunity. We focus on type 2 lymphocytes, namely ILC2s and Th2 cells, and apply high-throughput CRISPR screens to identify novel regulators of type 2 immune responses. We are a multidisciplinary laboratory combining molecular, in vitro and in vivo approaches to understand the underlying mechanisms of immune cell function in homeostasis and allergic diseases. By advancing our basic understanding of how immune cells develop and function, we aim to develop novel approaches to restoring immune balance and promoting tissue and organismal health.

Key words
type 2 immunity, innate lymphoid cells, ILC2, Th2, allergy, asthma, CRISPR screen, computational, transcriptomic, epigenetic, tissue immunity, mucosal immunity, neuroimmune

Program affiliation
General

Research summary
Circadian physiology and behavior

Key words
circadian rhythm, neuropeptide, GPCR, 2nd messengers, Drosophila