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Daniel Castro, PhD

Assistant Professor

Program affiliation
Neurosciences
Molecular Genetics and Genomics
Computational and Systems Biology

Research summary
Understanding the role of endogenous opioids in affective neuroscience and metabolic homeostasis

Key words
reward, valence, opioid, motivation, metabolism, diabetes

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Grant Challen, PhD

Assistant Professor

Program affiliation
Cancer Biology
Developmental Regenerative and Stem Cell Biology
Molecular Cell Biology
Molecular Genetics and Genomics

Research summary
Understanding the genetic and epigenetic mechanisms that regulate normal and leukemic stem cells

Key words
Hematopoietic stem cells, Leukemia stem cells, Epigenetic modifications

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Aisling Chaney, PhD

Assistant Professor

Program affiliation
Neurosciences

Research summary

Key words

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Hong Chen, PhD

Associate Professor

Program affiliation
Molecular Cell Biology
Neurosciences
Cancer Biology

Research summary
Advances the field of NeuroSonics by integrating breakthroughs in neuroscience and ultrasonics to deepen our understanding of brain function and transform the diagnosis and treatment of neurological diseases.

Key words
Brain, neuroscience, cancer biology, imaging, ultrasound

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Shiming Chen, PhD

Dr. Bernard and Janet R. Becker Distinguished Professor

Program affiliation
Molecular Genetics and Genomics
Developmental Regenerative and Stem Cell Biology
Neurosciences

Research summary
Molecular mechanisms regulating photoreceptor gene expression in healthy and diseased retinas

Key words
Gene expression regulation, transcription factors, epigenetic regulators, photoreceptor development and degeneration, mouse models, gene therapy

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Brian Clark, PhD

Assistant Professor

Program affiliation
Developmental Regenerative and Stem Cell Biology
Neurosciences
Molecular Genetics and Genomics

Research summary
Analysis of the temporally regulated program of retinal cell type specification.

Key words

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Jonathan Cooper, PhD

Professor

Program affiliation
Neurosciences
Molecular Genetics and Genomics
Developmental Regenerative and Stem Cell Biology
Computational and Systems Biology

Research summary
Disease mechanisms and treatments for inherited childhood neurodegeneration

Key words
Batten Disease, Neuronal Ceroid Lipofuscinosis, NCL, Lysosomal Storage Disease, pathogenesis, pre-clinical therapies, enzyme replacement, gene therapy

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Clair Crewe, PhD

Assistant Professor

Program affiliation
Molecular Cell Biology
Biochemistry Biophysics and Structural Biology

Research summary
Understanding extracellular vesicle (EV)-mediated signaling during homeostatic and pathologic metabolic regulation

Key words

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Nicholas Davidson, MD

Professor

Program affiliation
Molecular Cell Biology
Biochemistry Biophysics and Structural Biology
Biomedical Informatics and Data Science

Research summary
Mammalian gene expression: Regulation through mRNA editing and RNA stabilization

Key words
gene expression, RNA, cancer, mRNA editing, mRNA stability

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Patricia Dickson, MD

Centennial Professor

Program affiliation
Molecular Genetics and Genomics
Neurosciences

Research summary
Developing therapies and studying the impact of lysosomal storage disorders in animal models and in trials

Key words