Mentorship Certified
John Edwards, PhD
Associate Professor
- Email: jredwards@wustl.edu
Program affiliation
Computational and Systems Biology
Molecular Genetics and Genomics
Human and Statistical Genetics
Research summary
We develop new computational and experimental approaches to understand the roles of DNA methylation and hydroxymethylation in neurodevelopment and cancer
Key words
bioinformatics, cancer, cancer genomics, epigenetics, epigenomics, neurodevelopment, transcriptional regulation
Gabor Egervari, PhD
Assistant Professor
- Email: gabor@wustl.edu
Program affiliation
Molecular Genetics and Genomics
Biochemistry Biophysics and Structural Biology
Neurosciences
Molecular Cell Biology
Research summary
We aim to understand how metabolism influences epigenetics, gene expression and behavior, particularly in the context of substance use disorders and neurodegeneration
Key words
Metabolism, epigenetics, alcohol, addiction, neurodegeneration, Alzheimer’s
Lijuan Feng
Assistant Professor
- Email: l.feng@wustl.edu
Program affiliation
Molecular Genetics and Genomics
Developmental Regenerative and Stem Cell Biology
Molecular Cell Biology
Research summary
Our lab studies how disease-associated histone mutations disrupt chromatin and epigenetic regulation, contributing to developmental disorders, brain inflammation, and cancer. We take a multidisciplinary approach that combines biochemical and genomic assays, molecular genetics, cell biology, and both Drosophila and mouse models to investigate how these mutations impair development and drive tumorigenesis. Current projects focus on neurodevelopmental disorders, cancer-associated histone mutations, chromatin–immune crosstalk, and the discovery of chromatin-associated factors. Through this work, we aim to uncover fundamental mechanisms of chromatin dysregulation and identify new therapeutic targets.
Key words
Chromatin, Epigenetics, Gene Regulation, Cancer, Developmental Disorders, Brain Inflammation
Jennifer Foltz, PhD
Assistant Professor
- Email: jennifer.a.foltz@wustl.edu
Program affiliation
Computational and Systems Biology
Immunology
Cancer Biology
Molecular Genetics and Genomics
Biomedical Informatics and Data Science
Research summary
My research interests lie in integrating and applying novel computational biology techniques with mechanistic experimental immunology to understand drivers of response and resistance to NK cell therapies for cancer
Key words
natural killer cells, computational biology, single-cell sequencing, immunotherapy, nk cells