Biochemistry Biophysics and Structural Biology

Program affiliation
Biochemistry Biophysics and Structural Biology
Cancer Biology
Molecular Cell Biology
Molecular Microbiology and Microbial Pathogenesis

Research summary
The rational structure-based drug design and synthesis for cancer and infectious disease

Key words
protease, kinase, cancer, infection, lectin, chemistry, synthesis, drug discovery, peptidomimetic, inhibitor

Program affiliation
Molecular Cell Biology
Biochemistry Biophysics and Structural Biology

Research summary
we study the molecular mechanisms that regulate the architecture, dimensions and dynamics of actin filament networks, and tune them to support essential cellular functions including cell migration, intracellular trafficking and cytokinesis.

Key words
actin cytoskeleton, microtubule, single molecule, live cell imaging, protein transport, Golgi, confocal microscopy

Program affiliation
Plant and Microbial Biosciences
Biochemistry Biophysics and Structural Biology

Research summary
Exploring regulatory networks in metabolism - structural biology and biochemistry of plants and microbes

Key words
biochemistry, enzymology, plant biology, protein engineering, protein structure, structural biology

Program affiliation
Biochemistry Biophysics and Structural Biology

Research summary
Developing geometric algorithms for interpreting protein structures from low-resolution density maps produced by cryo-electron microscopy and X-ray crystallography

Key words
molecular imaging, geometric algorithms, anatomical modeling, computer graphics, biomedicine

Program affiliation
Cancer Biology
Molecular Cell Biology
Immunology
Biochemistry Biophysics and Structural Biology

Research summary
A major component of my research program is to (1) develop strategies for improving the therapeutic ratio of radiation therapy by increasing tumor sensitivity to radiation and limiting normal tissue toxicity and (2) understand the biological mechanisms of treatment resistance.

Key words
Cancer targeting, antibodies, Translational research, Radiation, Lung Cancer, Glioblastoma, Signaling mechanisms

Program affiliation
Molecular Cell Biology
Biochemistry Biophysics and Structural Biology

Research summary
Understand fundamental cellular and molecular mechanisms that drive the biogenesis and dynamics of intracellular membrane compartments

Key words
cytoskeleton, membranes, intracellular trafficking, organelle biogenesis, fluorescence, crystallography

Program affiliation
Cancer Biology
Molecular Genetics and Genomics
Molecular Cell Biology
Biochemistry Biophysics and Structural Biology

Research summary
clinical and translational research in gynecologic oncology, with a focus on ovarian cancer

Key words

Program affiliation
Neurosciences
Molecular Cell Biology
Biochemistry Biophysics and Structural Biology

Research summary
We study auditory coding and processing using in vivo methods such as two-photon imaging, optogenetics, inner ear drug/gene delivery, and hearing physiology recording.

Key words
Sensory research, Auditory research, Auditory circuit, In vivo two-photon imaging, Optogenetics, Electrophysiology, Drug delivery, Hearing loss, Ototoxicity, Ear

Program affiliation
Developmental Regenerative and Stem Cell Biology
Molecular Genetics and Genomics
Molecular Cell Biology
Biochemistry Biophysics and Structural Biology

Research summary
organismal aging; zinc homeostasis and roles of zinc during cell differentiation.

Key words
aging, metals, zinc, development, sperm activation, signal transduction, homeostasis

Program affiliation
Biochemistry Biophysics and Structural Biology

Research summary
Quantitative cardiovascular physiology, mathematical modeling of systems physiology, imaging

Key words
biophysics, cardiology, cardiovascular physiology, echocardiography, imaging, mathematical modeling