Cancer Biology

Program affiliation
Cancer Biology

Research summary
We develop and evaluate theranostic agents, dual modality diagnostic and therapeutic agents for disease applications. We considers questions of drug development, disease characterization and biological responses with a focus on near term translational relevance.

Key words
cancer, therapy, radiology, radiation oncology, theranostics

Program affiliation
Cancer Biology
Human and Statistical Genetics
Immunology
Molecular Genetics and Genomics

Research summary
Genomics of breast cancer etiology to identify targetable pathways

Key words
Genomics, biomarkers, metabolic imbalance, mammographic density, breast cancer, colorectal cancer, prevention,

Program affiliation
Molecular Microbiology and Microbial Pathogenesis
Computational and Systems Biology
Molecular Genetics and Genomics
Immunology
Cancer Biology

Research summary
We want to understand how microbes interact with humans so that we can identify new strategies to improve health. Our research integrates 'skinomics', metagenomics and host-microbial genetics to address how microbes influence skin physiology.

Key words
microbiome, skin, dermatology, skin diseases, infection, skin cancer, wound healing, environmental exposures

Program affiliation
Molecular Cell Biology
Molecular Microbiology and Microbial Pathogenesis
Immunology
Cancer Biology

Research summary
The bone microenvironment for cancer and infection

Key words
bone biology, osteoclast, cancer, metastasis, osteoporosis, microenvironment, osteoblast, osteomyelitis, infection

Program affiliation
Cancer Biology
Molecular Cell Biology
Molecular Genetics and Genomics
Biochemistry Biophysics and Structural Biology

Research summary
Understanding DNA repair mechanisms that impact cancer etiology and responses to chemotherapies

Key words
DNA repair and replication; Genomic instability in cancers; Oncogenes; BRCA-mutation

Program affiliation
Cancer Biology
Molecular Cell Biology
Molecular Genetics and Genomics

Research summary
DNA replication and repair, and the roles of these pathways on cancer initiation, progression and response to chemotherapy and immunotherapy

Key words
genome stability, DNA repair, DNA replication, chemotherapy response, cancer etiology

Program affiliation
Molecular Genetics and Genomics
Cancer Biology

Research summary
Genetics and genomics of blood cancer: mutation discovery and mouse models

Key words
cancer, functional genomics, gene expression profiling, hematopoiesis, stem cells, tumor biology

Program affiliation
Molecular Cell Biology
Biochemistry Biophysics and Structural Biology
Cancer Biology
Neurosciences

Research summary
We study how the major microtubule organizing center of animal cells, the centrosome, is formed and regulated to enable cell division and signaling

Key words
Centrosomes, cilia, microtubules, cytoskeleton, organelles, subcellular organization, cell dynamics, mitosis, cell cycle, cell biology, biochemistry

Program affiliation
Molecular Genetics and Genomics
Cancer Biology
Human and Statistical Genetics

Research summary
Detection and molecular classification of rare tumor cells to predict and mitigate cancer metastases

Key words
cancer, functional genomics, gene expression, pathogenesis, breast cancer

Program affiliation
Cancer Biology
Immunology

Research summary
We are focused on exploiting features of the tumor microenvironment for cancer therapy. Specifically, we study stromal - tumor cell interactions in pancreatic cancer with the goal of defining clinically relevant cancer biology.

Key words
pancreatic cancer, immunotherapy, myeloid cells, tumor microenvironment, CRISPR screening