General

Program affiliation
General

Research summary
History and philosophy of biology & medicine, general philosophy of science, biomedical ethics

Key words
cancer, genetics, evolution, risk, modeling

Program affiliation
General

Research summary

Key words

Program affiliation
General

Research summary
The evolution of sociality, cooperation, and cheating in a eukaryotic microbe, using experimental evolution, genomics, and other approaches

Key words
social interactions, evolution, microbiology, social amoebae, kin selection, moleuclar evolution, multicellularity, development, genomics

Program affiliation
General

Research summary
Systems analysis of neural information processing; bio-inspired sensors and algorithms

Key words
mathematical modeling, neurobiology, neurophysiology, sensory systems, smell, systems neuroscience

Program affiliation
General

Research summary
I am an evolutionary biologist and plant systematist. Of particular interest to me are plant/animal interactions, biogeography, and plant sexual systems

Key words
Evolution, plant systematics, nomenclature, biogeography, plant/animal interactions, sexual systems, sex chromosomes

Program affiliation
General

Research summary
Statistical genetics; complex disease genetics; methods in statistical genetics

Key words
mathematical modeling, epidemiology, genetics

Program affiliation
General

Research summary
Our projects primarily focus on the chelation of radionuclides, such as 64Cu and 89Zr positron-emission tomography (PET) imaging, and 177Lu, 67Cu, and 90Y for radiotherapeutic applications. My laboratory has developed both peptide- and antibody-based radiopharmaceuticals. Notably, I was the first to publish on a 64Cu-labeled peptide, a derivative of which is now being evaluated in human clinical trials by a pharmaceutical company for both imaging and therapy. The translational impact of my work is evident in the FDA approval of similar agents using 177Lu and 64Cu.

Key words
PET imaging, theranostics, radiometal chemistry

Program affiliation
General

Research summary
Molecular mechanisms in pediatric brain tumorigenesis

Key words
tumor biology, signal transduction, stem cells, neural development, sexual dimorphism, circadaian rhythm, chemokines, cAMP

Program affiliation
General

Research summary
Development of nano-scale biomaterials for engaging the immune system to induce protective antibody and cell-mediated immune responses against diseases

Key words

Program affiliation
General

Research summary
CNS/lymphocyte interactions regulating inflammation and pathogenesis in a mouse model of multiple sclerosis

Key words
apoptosis, autoimmunity, imaging, inflammation, multiple sclerosis