Immunology
Hua Pan, PhD
Associate Professor
- Email: hpan@wustl.edu
Program affiliation
Cancer Biology
Biochemistry Biophysics and Structural Biology
Immunology
Research summary
https://sites.wustl.edu/panlab/
Key words
Onco-Nephrology, Cardio-Oncology, Cancer, MRI, Gene/drug delivery, Machine Learning
Guangyong Peng, MD, PhD
Professor
- Email: pengg@wustl.edu
Program affiliation
Immunology
Cancer Biology
Neurosciences
Research summary
Understanding the role of immune system in the pathogenesis of cancer and age-related neurological disorders (Alzheimer's disease), and then to develop effective strategies for manipulation of immune cell fate and function for disease prevention and immunotherapy.
Key words
Senescent T cells, Regulatory T cells (Tregs), Dendritic cells (DCs), Tumor microenvironment, Alzheimer's disease, Cell metabolism, Toll-like receptors, Immunotherapy
David Perlmutter, MD
Spencer T. and Ann W. Olin Distinguished Professor
- Email: perlmutterd@wustl.edu
Program affiliation
Molecular Cell Biology
Immunology
Molecular Genetics and Genomics
Research summary
Pathobiology of liver disease from accumulation and proteotoxicity of misfolded proteins in α1-antitrypsin deficiency; role of autophagy in biology and treatment of disorders caused by misfolded proteins
Key words
α1-antitrypsin deficiency, protein secretion, protein degradation, autophagy, proteostasis, autophagy enhancer drugs
Stephen Persaud, MD,PhD
Assistant Professor
- Email: persaud@wustl.edu
Program affiliation
Immunology
Developmental Regenerative and Stem Cell Biology
Cancer Biology
Research summary
Optimizing hematopoietic stem cell transplantation as definitive therapy for non-malignant blood diseases
Key words
sickle cell disease, hematopoietic stem cell transplantation, antibody-based immunotherapy, conditioning, JAK inhibitors, gene editing
Jennifer Philips, MD, PhD
Theodore and Bertha Bryan Professor
- Email: philips.j.a@wustl.edu
Program affiliation
Molecular Microbiology and Microbial Pathogenesis
Immunology
Molecular Cell Biology
Research summary
Immune Evasion by Mycobacterium tuberculosis
Key words
tuberculosis, host-pathogen interactions, innate immunity, autophagy, lipid metabolism, phagosome maturation, antigen presentation, macrophage
Sumanth Prabhu, MD
Tobias & Hortense Lewin Distinguished Professor of Cardiovascular Disease
- Email: prabhu@wustl.edu
Program affiliation
Biochemistry Biophysics and Structural Biology
Immunology
Molecular Cell Biology
Research summary
Key words
Sidharth Puram, MD, PhD
Lindburg Professor and Head of the Department of Otolaryngology
- Email: sidpuram@wustl.edu
Program affiliation
Molecular Genetics and Genomics
Cancer Biology
Computational and Systems Biology
Immunology
Developmental Regenerative and Stem Cell Biology
Research summary
Understanding the role of tumor heterogeneity in cancer biology, including its contributions to cancer development, growth, metastasis, and treatment resistance mechanisms, in order to translate these insights into new diagnostics and novel therapeutics
Key words
tumor heterogeneity; single cell; spatial transcriptomics; head and neck cancer; signaling
Gwendalyn Randolph, PhD
Emil R. Unanue Distinguished Professor
- Email: gjrandolph@wustl.edu
Program affiliation
Immunology
Molecular Cell Biology
Molecular Microbiology and Microbial Pathogenesis
Research summary
We focus on inter-organ communication and the transit of cells and molecules out of tissues in healthy and disease states
Key words
lymphatic vessels, lymph nodes, IBD, monocytes, macrophages, high-density lipoprotein, peritoneal tumor metastasis, peritoneal macrophages
Kodi Ravichandran, PhD
Robert L. Kroc Professor and BJC Investigator
- Email: kodi@wustl.edu
Program affiliation
Immunology
Molecular Cell Biology
Research summary
Apoptotic cell clearance mechanisms in health and disease
Key words
Felipe Ribeiro, PhD
Assistant Professor
- Email: dfelipe@wustl.edu
Program affiliation
Immunology
Molecular Microbiology and Microbial Pathogenesis
Neurosciences
Research summary
Understanding the neuroimmune basis of infectious and non-infectious diseases
Key words
Pain and sensory disorders; Infectious diseases; Neuroimmunology; Host-microbe interactions