Immunology

Program affiliation
Immunology
Computational and Systems Biology
Neurosciences

Research summary
The Paley Lab studies mechanisms of autoimmunity with a particular focus on inflammation in immune-privileged organs. Our focus is on HLA alleles and corresponding T cell receptors that drive human autoimmune diseases. We use a combination of sequencing and flow cytometric techniques from our large biorepository to better understand how autoimmunity develops..

Key words
T cells, autoimmunity, immunology, T cell receptor, TCR

Program affiliation
Cancer Biology
Biochemistry Biophysics and Structural Biology
Immunology

Research summary
https://sites.wustl.edu/panlab/

Key words
Onco-Nephrology, Cardio-Oncology, Cancer, MRI, Gene/drug delivery, Machine Learning

Program affiliation
Immunology
Cancer Biology
Neurosciences

Research summary
Understanding the role of immune system in the pathogenesis of cancer and age-related neurological disorders (Alzheimer's disease), and then to develop effective strategies for manipulation of immune cell fate and function for disease prevention and immunotherapy.

Key words
Senescent T cells, Regulatory T cells (Tregs), Dendritic cells (DCs), Tumor microenvironment, Alzheimer's disease, Cell metabolism, Toll-like receptors, Immunotherapy

Program affiliation
Molecular Cell Biology
Immunology
Molecular Genetics and Genomics

Research summary
Pathobiology of liver disease from accumulation and proteotoxicity of misfolded proteins in α1-antitrypsin deficiency; role of autophagy in biology and treatment of disorders caused by misfolded proteins

Key words
α1-antitrypsin deficiency, protein secretion, protein degradation, autophagy, proteostasis, autophagy enhancer drugs

Program affiliation
Immunology
Developmental Regenerative and Stem Cell Biology
Cancer Biology

Research summary
Optimizing hematopoietic stem cell transplantation as definitive therapy for non-malignant blood diseases

Key words
sickle cell disease, hematopoietic stem cell transplantation, antibody-based immunotherapy, conditioning, JAK inhibitors, gene editing

Program affiliation
Molecular Microbiology and Microbial Pathogenesis
Immunology
Molecular Cell Biology

Research summary
Immune Evasion by Mycobacterium tuberculosis

Key words
tuberculosis, host-pathogen interactions, innate immunity, autophagy, lipid metabolism, phagosome maturation, antigen presentation, macrophage

Program affiliation
Biochemistry Biophysics and Structural Biology
Immunology
Molecular Cell Biology

Research summary

Key words

Program affiliation
Molecular Genetics and Genomics
Cancer Biology
Computational and Systems Biology
Immunology
Developmental Regenerative and Stem Cell Biology

Research summary
Understanding the role of tumor heterogeneity in cancer biology using single cell and spatial techniques, with an emphasis on how tumor subpopulations (malignant, stromal, and immune cells) drive cancer development, growth, metastasis, and treatment resistance. We are particularly focused on how to translate these insights into new diagnostics and novel therapeutics.

Key words
tumor heterogeneity; single cell; spatial transcriptomics; head and neck cancer; signaling

Program affiliation
Immunology
Molecular Cell Biology
Molecular Microbiology and Microbial Pathogenesis
Molecular Genetics and Genomics

Research summary
We focus on inter-organ communication and the transit of cells and molecules out of tissues in healthy and disease states

Key words
lymphatic vessels, lymph nodes, IBD, monocytes, macrophages, high-density lipoprotein, peritoneal tumor metastasis, peritoneal macrophages

Program affiliation
Immunology
Molecular Cell Biology

Research summary
Apoptotic cell clearance mechanisms in health and disease

Key words