Immunology

Program affiliation
Immunology

Research summary
My research interests are in the genetics of immune-mediated diseases and the fundamental mechanisms of immune cell activation, immune dysregulation, and immunological tolerance. My current work focuses on delineating the mechanisms underlying a monogenic syndrome of early-onset autoimmunity caused by gain-of-function (GOF) mutations in STAT3.

Key words
Immune dysregulation, inborn errors of immunity, Treg, STAT, Pediatric

Program affiliation
Immunology
Cancer Biology

Research summary
Cytokine receptor signaling and immunological protection against tumor development

Key words
cancer, lymphocyte, cytokine, signal transduction, tumor editing

Program affiliation
Developmental Regenerative and Stem Cell Biology
Immunology
Molecular Genetics and Genomics

Research summary
Regulation of hematopoietic stem cells (HSCs) by inflammation

Key words

Program affiliation
Biochemistry Biophysics and Structural Biology
Computational and Systems Biology
Immunology
Molecular Microbiology and Microbial Pathogenesis

Research summary
Understand the structural mechanisms of host-pathogen interactions and the inflammasome signaling

Key words
structural biology, innate immunity, pattern recognition receptors, immune recognition, inflammasomes

Program affiliation
Developmental Regenerative and Stem Cell Biology
Molecular Cell Biology
Molecular Genetics and Genomics
Immunology
Neurosciences

Research summary
My research program integrates cardiovascular physiology, stem cell biology, developmental biology, functional genomics, and cardio-oncology to investigate molecular mechanisms of congenital and acquired cardiovascular diseases. My laboratory specializes in developing innovative protocols for generating authentic cardiovascular cell types from human induced pluripotent stem cells (iPSCs), advancing cardiovascular precision medicine. We aim to bridge basic science and clinical translation through disease modeling, therapeutic target identification, and adverse outcome prevention.

Key words
iPSC, CRISPR, organoid, cardiovascular, precision medicine, cardio-oncology

Program affiliation
Cancer Biology
Molecular Cell Biology
Biochemistry Biophysics and Structural Biology
Immunology

Research summary
Development and evaluation of small- and macro-molecular agents for multi-modal molecular imaging of cancer and cardiovascular diseases

Key words

Program affiliation
Molecular Microbiology and Microbial Pathogenesis
Molecular Genetics and Genomics
Immunology

Research summary
Cellular and molecular basis of intracellular parasitism by protozoan parasites

Key words
cell-signaling, kinases, transcription, chromatin, pathogenesis, genetics, genomics, chemical biology, innate immunity

Program affiliation
Immunology
Cancer Biology
Computational and Systems Biology
Biochemistry Biophysics and Structural Biology

Research summary
Understanding how synthetic antigen receptors direct T cell function and dysfunction in the treatment of blood cancers

Key words
CAR T cell therapy, immunotherapy for cancer, T cell signaling, T cell dysfunction, lineage decisions

Program affiliation
Molecular Microbiology and Microbial Pathogenesis
Immunology
Plant and Microbial Biosciences
Biochemistry Biophysics and Structural Biology

Research summary
Molecular pathogenesis of Mycobacterium tuberculosis

Key words
bacteria, gene regulation, molecular genetics, microbiology, pathogenesis, transcription, infectious disease, innate immunity

Program affiliation
Molecular Microbiology and Microbial Pathogenesis
Immunology

Research summary
Investigate the genetic and environmental factors that underlie the mechanistic basis for the heterogeneity in outcomes in response to infection

Key words